Maneuvering safely through the environment is central to survival of almost all species. The
ability to do this depends on learning and remembering locations. This capacity is encoded …

In recent years, gene therapy has been raising hopes toward viable treatment strategies for
rare genetic diseases for which there has been almost exclusively supportive treatment. We …

Angelman syndrome (AS) is a severe neurodevelopmental disorder that results from loss of
function of the maternal ubiquitin protein ligase E3A (UBE3A) allele. Due to neuron-specific …

“Angelman syndrome”(AS) is a neurodevelopmental disorder whose main features are
intellectual disability, lack of speech, seizures, and a characteristic behavioral profile. The …

Angelman syndrome is a devastating neurogenetic disorder for which there is currently no
effective treatment. It is caused by mutations or epimutations affecting the expression or …

Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …

Angelman syndrome (AS) is a neurodevelopment disorder characterized by severe
cognitive impairment and a high rate of autism. AS is caused by disrupted neuronal …

Although it has been known for decades that hippocampal calcium/calmodulin (CaM)-
dependent protein kinase II (CaMKII) plays an essential role in learning and memory …

Angelman Syndrome (AS) is a severe cognitive disorder caused by loss of neuronal
expression of the E3 ubiquitin ligase UBE3A. In an AS mouse model, we previously reported …

Significance: Impairment of the ubiquitin-proteasome system (UPS) has been implicated in
the pathogenesis of a wide variety of neurodegenerative disorders, including Alzheimer's …