Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Overcoming endocrine resistance in breast cancer

AB Hanker, DR Sudhan, CL Arteaga - Cancer cell, 2020 - cell.com
Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype.
Treatment of ER+ breast cancer comprises interventions that suppress estrogen production …

Invasive lobular carcinoma of the breast: the increasing importance of this special subtype

AE McCart Reed, L Kalinowski, PT Simpson… - Breast Cancer …, 2021 - Springer
Invasive lobular carcinoma (ILC) is the most common of the breast cancer special types,
accounting for up to 15% of all breast cancer cases. ILCs are noted for their lack of E …

[HTML][HTML] Current and future diagnostic and treatment strategies for patients with invasive lobular breast cancer

K Van Baelen, T Geukens, M Maetens… - Annals of …, 2022 - Elsevier
Background Invasive lobular breast cancer (ILC) is the second most common type of breast
cancer after invasive breast cancer of no special type (NST), representing up to 15% of all …

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance

LA Martin, R Ribas, N Simigdala, E Schuster… - Nature …, 2017 - nature.com
Resistance to endocrine therapy remains a major clinical problem in breast cancer. Genetic
studies highlight the potential role of estrogen receptor-α (ESR1) mutations, which show …

The lncRNA NEAT1 facilitates cell growth and invasion via the miR-211/HMGA2 axis in breast cancer

X Li, S Wang, Z Li, X Long, Z Guo, G Zhang, J Zu… - International journal of …, 2017 - Elsevier
Long non-coding RNAs play a significant role in cancer metastasis. Studies have
demonstrated that LncRNA NEAT1 promotes cancer progression. We aimed to explore …

Comprehensive review of molecular mechanisms and clinical features of invasive lobular cancer

N Pramod, A Nigam, M Basree, R Mawalkar… - The …, 2021 - academic.oup.com
Invasive lobular carcinoma (ILC) accounts for 10% to 15% of breast cancers in the United
States, 80% of which are estrogen receptor (ER)-positive, with an unusual metastatic pattern …

Invasive lobular breast cancer as a distinct disease: implications for therapeutic strategy

J Luveta, RM Parks, DM Heery, KL Cheung… - Oncology and …, 2020 - Springer
Abstract Invasive lobular carcinoma comprises 10–15% of all breast cancers and is
increasingly recognised as a distinct and understudied disease compared with the …

Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

T Du, MJ Sikora, KM Levine, N Tasdemir… - Breast Cancer …, 2018 - Springer
Background Invasive lobular breast carcinoma (ILC) is a histological subtype of breast
cancer that is characterized by loss of E-cadherin and high expression of estrogen receptor …

Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1

G Sflomos, L Battista, P Aouad… - EMBO molecular …, 2021 - embopress.org
Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast
cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from …