The LINC and NPC relationship–it's complicated!

Z Jahed, M Soheilypour, M Peyro… - Journal of cell …, 2016 - journals.biologists.com
The genetic information of eukaryotic cells is enclosed within a double-layered nuclear
envelope, which comprises an inner and outer nuclear membrane. Several transmembrane …

How and why chromosomes interact with the cytoskeleton during meiosis

HJ Kim, C Liu, AF Dernburg - Genes, 2022 - mdpi.com
During the early meiotic prophase, connections are established between chromosomes and
cytoplasmic motors via a nuclear envelope bridge, known as a LINC (linker of …

LINC complexes as regulators of meiosis

B Burke - Current opinion in cell biology, 2018 - Elsevier
Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell
division cycles with a single round of DNA replication meiosis provides a mechanism to …

Cell Biology of the Caenorhabditis elegans Nucleus

O Cohen-Fix, P Askjaer - Genetics, 2017 - academic.oup.com
Studies on the Caenorhabditis elegans nucleus have provided fascinating insight to the
organization and activities of eukaryotic cells. Being the organelle that holds the genetic …

Molecular insights into the mechanisms of SUN1 oligomerization in the nuclear envelope

Z Jahed, D Fadavi, UT Vu, E Asgari, GWG Luxton… - Biophysical journal, 2018 - cell.com
The LINC complex is found in a wide variety of organisms and is formed by the transluminal
interaction between outer-and inner-nuclear-membrane KASH and SUN proteins …

A chromodomain protein mediates heterochromatin-directed piRNA expression

X Huang, P Cheng, C Weng, Z Xu… - Proceedings of the …, 2021 - National Acad Sciences
PIWI-interacting RNAs (piRNAs) play significant roles in suppressing transposons,
maintaining genome integrity, and defending against viral infections. How piRNA source loci …

In Vitro Synthesis and Reconstitution Using Mammalian Cell-Free Lysates Enables the Systematic Study of the Regulation of LINC Complex Assembly

S Majumder, YY Hsu, H Moghimianavval… - Biochemistry, 2022 - ACS Publications
Understanding the structure and structure–function relationships of membrane proteins is a
fundamental problem in biomedical research. Given the difficulties inherent to performing …

Pairing of homologous chromosomes in C. elegans meiosis requires DEB-1 - an orthologue of mammalian vinculin

J Rohožková, L Hůlková, J Fukalová, P Flachs… - Nucleus, 2019 - Taylor & Francis
During meiosis, homologous chromosomes undergo a dramatic movement in order to
correctly align. This is a critical meiotic event but the molecular properties of this …

[图书][B] Knockdown of the SUN-1/ZYG-12 LINC complex perturbs nucleolar assembly in early Caenorhabditis elegans embryogenesis

M Couture - 2020 - search.proquest.com
The nucleolus has been studied for the past 200 years, leading it to be a well characterized
membraneless organelle. It is responsible for many cellular functions, notably ribosome …

LINC Complex in Mechanobiology: Role of Nesprin 4 in Secretory Epithelial Cells

A Khilan - 2020 - search.proquest.com
LINC complex proteins connect the nucleoskeleton to the cytoskeleton, which is an
important link for processes such as maintaining epithelial cell polarization and …