New Findings What is the topic of this review? Pain in infancy. What advances does it
highlight? New neurophysiological research on pain processing in the human infant brain …

For a long time, the capacity of the newborn infant to feel pain was denied. Today it is clear
that the nociceptive system, even if still immature, is functional enough in the newborn infant …

Newborn infants display strong nociceptive behavior in response to tissue damaging stimuli,
and this is accompanied by nociceptive activity generated in subcortical and cortical areas of …

A comprehensive assessment of pain extends beyond measuring the intensity of pain to
also include: site and radiation of pain; onset, aggravating and relieving factors; character of …

The nociceptive network, responsible for transmission of nociceptive signals that generate
the pain experience, is not fully developed at birth. Descending serotonergic modulation of …

Noxious stimulation at critical stages of development has long-term consequences on
somatosensory processing in later life, but it is not known whether this developmental …

Forty-five years ago, Patrick Wall published his John J Bonica lecture “On the relation of
injury to pain.” 90 In this lecture, he argued that pain is better classified as an awareness of a …

In adults, nociceptive reflexes and behavioral responses are modulated by a network of
brain regions via descending projections to the spinal dorsal horn [1]. Coordinated …

Understanding mechanisms that underly the transition from acute to chronic pain and
identifying potential targets for preventing or minimizing this progression have specific …

Pain in newborn children should be prevented due to negative short-and long-term
consequences. A good understanding of the development of the nociceptive system in …