Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …

Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

Migraine is a common, disabling neurological disorder characterized by multiple phases:
premonitory, aura, headache, postdrome, and interictal. Our understanding of the …

While chronic pain is considered by some to be a CNS disease, little is understood about
underlying neurobiological mechanisms. Addiction models have heuristic value in this …

A Systems Neuroscience Approach to Migraine: Neuron Skip to Main Content Advertisement
Neuron This journal offers authors two options (open access or subscription) to publish …

Background Migraine is a highly prevalent primary headache disorder. Despite a high
burden of disease, key disease mechanisms are not entirely understood. Functional …

Background Resting-state functional connectivity (FC) MRI has widely been used to
understand migraine pathophysiology and to identify an imaging marker of the disorder …

Objectives To summarize and meta-analyze studies on changes in grey matter (GM) in
patients with migraine. We aimed to determine whether there are concordant structural …

Migraine pathophysiology includes altered brainstem excitability, and recent
neuromodulatory approaches aimed at controlling migraine episodes have targeted key …

After 35 years since the introduction of the International Classification of Headache
Disorders (ICHD), we are living in the era of the second great revolution in migraine …