Background Colorectal cancer (CRC) is one of the leading cause of cancer deaths
worldwide. Since CRC is largely asymptomatic until alarm features develop to advanced …

Ezrin, as encoded by the EZR gene, is a member of the Ezrin/Radixin/Moesin (ERM) family.
The ERM family includes three highly related actin filament binding proteins, Ezrin, Radixin …

In solid tumors, cancer stem cells (CSCs) or tumor-initiating cells (TICs) are often found in
hypoxic niches. Nevertheless, the influence of hypoxia on TICs is poorly understood. Using …

The merlin-ERM (ezrin, radixin, moesin) family of proteins plays a central role in linking the
cellular membranes to the cortical actin cytoskeleton. Merlin regulates contact inhibition and …

Cancer metastasis is the primary cause of morbidity and mortality in cancer as it remains the
most complicated, devastating, and enigmatic aspect of cancer. Several decades of …

In the last decade, pathway-specific targeted therapy has revolutionized colorectal cancer
(CRC) treatment strategies. This type of therapy targets a tumor-vulnerable spot formed …

The protein ezrin has been shown to enhance cancer cell motility and invasion leading to
malignant behaviours in solid tumours, but a similar regulatory function in the early …

Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic
colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a …

About one million people per year develop colorectal cancer (CRC) and approximately half
of them die. The extent of the disease (ie local invasion at the time of diagnosis) is a key …

Ezrin is a member of the ERM (ezrin/radixin/moesin) family of proteins that links cortical
cytoskeleton to the plasma membrane. High expression of ezrin correlates with poor …