Discovery of 8-hydroxy-2-quinoline carbaldehyde derivatives as inhibitors for M1 aminopeptidase of leishmania donovani
M1 aminopeptidase is a metallopeptidase that plays a vital role in protein catabolism and
has been identified as a validated drug target in various parasites; however, our …
has been identified as a validated drug target in various parasites; however, our …
Regulation of volume-regulated anion channels alters sensitivity to platinum chemotherapy
LER Feldman, S Mohapatra, RT Jones, M Scholtes… - Science …, 2024 - science.org
Cisplatin-based chemotherapy is used across many common tumor types, but resistance
reduces the likelihood of long-term survival. We previously found the puromycin-sensitive …
reduces the likelihood of long-term survival. We previously found the puromycin-sensitive …
Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase
The endogenous opioid system regulates pain through local release of neuropeptides and
modulation of their action on opioid receptors. However, the effect of opioid peptides, the …
modulation of their action on opioid receptors. However, the effect of opioid peptides, the …