Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …

Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …

Genome-wide association studies (GWAS) have identified more than 40 loci associated with
Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways …

Schizophrenia is one of the most widespread and complex mental disorders. To
characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing …

Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …

Most studies of gene expression in the brains of individuals with schizophrenia have
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …

Obesity-associated morbidity is exacerbated by abdominal obesity, which can be measured
as the waist-to-hip ratio adjusted for the body mass index (WHRadjBMI). Here we identify …

Identification of risk variants for neuropsychiatric diseases within enhancers underscores the
importance of understanding population-level variation in enhancer function in the human …

The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation
and the development of more effective therapies. Here, we performed single-cell dissection …

Neuroinflammation has been implicated in multiple brain disorders but the extent and the
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …