Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each
other to regulate gene expression by altering chromatin structure. Aberrant HDAC activity …

The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-
promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over …

Summary p53 may operate as an intracellular antiviral defense mechanism. To circumvent it,
SARS viruses adopt a kidnap and exploit strategy also shared by several viruses with …

Abstract MicroRNA (miR)-142 is up-regulated in the brain in HIV and SIV encephalitis
(SIVE). We identified the cell types where miR-142 is up-regulated and its relevant …

Human immunodeficiency virus (HIV) relies heavily on the host cellular machinery for
production of viral progeny. To exploit cellular proteins for replication and to overcome host …

Sirtuins are a family of NAD+-dependent protein deacetylases, which regulate cell survival
and energy metabolism, inflammation and cancer. Recent studies have shown that sirtuin-1 …

The disruption of apoptotic cell death process is closely associated with the etiology of
various diseases, including cancer. Permanent viral infections can cause different types of …

Resveratrol is a natural phenolic product found in some plants in response to stress and has
been linked to the many health benefits of red wine. Over the past several decades, a great …

HIV-Associated neurocognitive disorder (HAND) is one of the major concerns since it
persists in 40% of this population. Nowadays, HAND neuropathogenesis is considered to be …

Nampt/Visfatin/PBEF is a primary, rate-limiting enzyme involved in NAD+ biosynthesis,
which serves as a pivotal substance for proteins, and is required for cell growth, survival …