Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …

Doxorubicin is one of the most important anti-cancer chemotherapeutic drugs, being widely
used for the treatment of solid tumors and acute leukemias. The action of doxorubicin and …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

While the eukaryotic genome is the same throughout all somatic cells in an organism, there
are specific structures and functions that discern one type of cell from another. These …

Chromatin structure creates barriers for each step in eukaryotic transcription. Here we
discuss how the activities of two major classes of chromatin-modifying complexes, ATP …

The Snf2 family of helicase-related proteins includes the catalytic subunits of ATP-
dependent chromatin remodelling complexes found in all eukaryotes. These act to regulate …

RNA helicases of the DEAD box and related DExD/H proteins form a very large superfamily
of proteins conserved from bacteria and viruses to humans. They have seven to eight …

Chromatin remodellers are specialized multi-protein machines that enable access to
nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All …

Epigenetic modifications characterized by DNA methylation, histone modifications, and
chromatin remodeling are important regulators in a number of biological processes …

▪ Abstract It has been a long-standing challenge to decipher the principles that enable cells
to both organize their genomes into compact chromatin and ensure that the genetic …