Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond

L Ravindar, SA Hasbullah, KP Rakesh… - European Journal of …, 2024 - Elsevier
Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds
that appear as a significant assembly motif for developing new drug entities. Aminoquinoline …

The role of graphene quantum dots in cutting‐edge medical therapies

K Arab, A Jafari, F Shahi - Polymers for Advanced …, 2024 - Wiley Online Library
Graphene quantum dots (GQDs), owing to their unique optical, electrical, and chemical
properties, have emerged as promising nanomaterials for various biomedical applications …

Exploring the antimalarial and antioxidant efficacy of transition metal (II) chelates of thiosemicarbazone ligands: spectral investigations, molecular docking, DFT, MESP …

J Devi, B Kumar, A Dubey, A Tufail, A Boora - BioMetals, 2024 - Springer
Malaria, a relentless and ancient adversary, continues to cast its shadow over vast swathes
of the globe, afflicting millions of people and have a heavy toll on human health and well …

Recent developments of P-glycoprotein inhibitors and its structure–activity relationship (SAR) studies

X Zhao, J Di, D Luo, Y Vaishnav, N Nuralieva… - Bioorganic …, 2024 - Elsevier
Abstract P-glycoprotein (P-gp) over-expression is a key factor in multi-drug resistance
(MDR), which is a major factor in the failure of cancer treatment. P-gp inhibitors have been …

Metal-insulator-metal plasmonic sensor utilizing grating-defect waveguide and cavities for temperature sensing and biological applications

M Ghanavati, F Emami, MA Karami - Physica Scripta, 2024 - iopscience.iop.org
This paper proposes a novel plasmonic temperature and refractive index (RI) sensor that
utilizes a Metal-Insulator-Metal (MIM) waveguide with two neighboring hexagonal cavities …

Novel Benzotriazole‐β‐lactam Derivatives as Antimalarial Agents: Design, Synthesis, Biological Evaluation and Molecular Docking Studies

M Aye, A Jarrahpour, Z Haghighijoo… - Chemistry & …, 2024 - Wiley Online Library
Many people around the world suffer from malaria, especially in tropical or subtropical
regions. While malaria medications have shown success in treating malaria, there is still a …

Evaluation of anti-inflammatory and anti-tubercular activity of 4-methyl-7-substituted coumarin hybrids and their structure activity relationships

M Nibin Joy, MR Guda, GV Zyryanov - Pharmaceuticals, 2023 - mdpi.com
Four sets of previously synthesized 4-methyl-7-substituted coumarin derivatives were
screened for their in vitro anti-inflammatory and anti-tubercular activities. The anti …

Design, synthesis and molecular docking study of novel quinoline–triazole molecular hybrids as anticancer agents

RD Bakale, AN Bhagat, UV Mhetre, SV Londhe… - Journal of Molecular …, 2025 - Elsevier
A series of novel thirty-three quinoline-triazole molecular hybrids were designed and
synthesized via Copper catalyzed azide-alkyne cycloaddition (CuAAC) strategy. The in-vitro …

Special Issue “Hybrid Drugs: Design and Applications”

P Singh, V Kumar - Pharmaceuticals, 2023 - mdpi.com
The widely held belief in the potential superiority of agents capable of modulating multiple
biological targets has led to the adoption of molecular hybridization as an effective …

Study of physiochemical properties of trisubstituted pyrazole derivatives using polar aprotic solvents

P Devi, H Anand, R Pundeer, S Kumar - Scientific Reports, 2025 - nature.com
Pyrazole derivatives are aromatic heterocyclic compounds endowed with multifaceted
applications. In the present study 1, 3, 4-trisubstituted pyrazoles derivatives have been …