The challenge of HIV-1 subtype diversity

BS Taylor, ME Sobieszczyk… - … England Journal of …, 2008 - Mass Medical Soc
HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as
classifiable into distinct subtypes needs to reflect the reality of the constant emergence of …

Predictors of disease progression in HIV infection: a review

SE Langford, J Ananworanich, DA Cooper - AIDS research and therapy, 2007 - Springer
During the extended clinically latent period associated with Human Immunodeficiency Virus
(HIV) infection the virus itself is far from latent. This phase of infection generally comes to an …

Randomized, double‐blind, placebo‐controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV‐1 vaccine among injection drug users in Bangkok …

P Pitisuttithum, P Gilbert, M Gurwith… - The Journal of …, 2006 - academic.oup.com
Abstract Background. In Thailand, phase 1/2 trials of monovalent subtype B and bivalent
subtype B/E (CRF01_AE) recombinant glycoprotein 120 human immunodeficiency virus …

Quantitative detection of increasing HIV type 1 antibodies after seroconversion: a simple assay for detecting recent HIV infection and estimating incidence

BS Parekh, MS Kennedy, T Dobbs, CP Pau… - AIDS research and …, 2002 - liebertpub.com
We have devised a simple enzyme immunoassay (EIA) that detects increasing levels of anti-
HIV IgG after seroconversion and can be used for detecting recent HIV-1 infection. Use of a …

Implications of HIV diversity for the HIV-1 pandemic

J Hemelaar - Journal of Infection, 2013 - Elsevier
HIV-1 genetic variability within individuals and populations plays a central role in the HIV
pandemic. Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV …

Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1—positive persons in Uganda

P Kaleebu, N French, C Mahe, D Yirrell… - The Journal of …, 2002 - academic.oup.com
The effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on
disease progression was investigated in 1045 adults in Uganda. At enrollment and every 6 …

Impact of HIV-1 viral subtype on disease progression and response to antiretroviral therapy

PJ Easterbrook, M Smith, J Mullen, S O'Shea… - Journal of the …, 2010 - Springer
Background Our intention was to compare the rate of immunological progression prior to
antiretroviral therapy (ART) and the virological response to ART in patients infected with …

Human immunodeficiency virus superinfection and recombination: current state of knowledge and potential clinical consequences

JT Blackard, DE Cohen, KH Mayer - Clinical Infectious Diseases, 2002 - academic.oup.com
Superinfection with multiple strains or subtypes of the human and simian immunodeficiency
viruses has been documented. Recent increases in the prevalences of both unprotected …

T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces

BT Korber, NL Letvin, BF Haynes - Journal of virology, 2009 - Am Soc Microbiol
The global spread of human immunodeficiency virus (HIV) and the human suffering left in its
wake have made AIDS a global heath priority. Yet the capacity of HIV to mutate and evolve …

CRF01_AE subtype is associated with X4 tropism and fast HIV progression in Chinese patients infected through sexual transmission

Y Li, Y Han, J Xie, L Gu, W Li, H Wang, W Lv, X Song… - Aids, 2014 - journals.lww.com
Background: The molecular epidemiology of the HIV-1 CRF01_AE subtype as a risk factor
for fast HIV-1 progression remains poorly understood. Methods: We analyzed HIV-1 tropism …