Insights and opportunities for deep brain stimulation as a brain circuit intervention

WJ Neumann, A Horn, AA Kühn - Trends in Neurosciences, 2023 - cell.com
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

[HTML][HTML] Connectomic deep brain stimulation for obsessive-compulsive disorder

JC Baldermann, T Schüller, S Kohl, V Voon, N Li… - Biological …, 2021 - Elsevier
Obsessive-compulsive disorder is among the most disabling psychiatric disorders. Although
deep brain stimulation is considered an effective treatment, its use in clinical practice is not …

Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging

A Horn, N Li, TA Dembek, A Kappel, C Boulay, S Ewert… - Neuroimage, 2019 - Elsevier
Deep brain stimulation (DBS) is a highly efficacious treatment option for movement disorders
and a growing number of other indications are investigated in clinical trials. To ensure …

Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease

AS Ríos, S Oxenford, C Neudorfer, K Butenko… - Nature …, 2022 - nature.com
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with
mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that …

[HTML][HTML] Lead-DBS v3. 0: Mapping deep brain stimulation effects to local anatomy and global networks

C Neudorfer, K Butenko, S Oxenford, N Rajamani… - Neuroimage, 2023 - Elsevier
Following its introduction in 2014 and with support of a broad international community, the
open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform …

A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

N Li, JC Baldermann, A Kibleur, S Treu… - Nature …, 2020 - nature.com
Multiple surgical targets for treating obsessive-compulsive disorder with deep brain
stimulation (DBS) have been proposed. However, different targets may modulate the same …

Connectivity profile predictive of effective deep brain stimulation in obsessive-compulsive disorder

JC Baldermann, C Melzer, A Zapf, S Kohl… - Biological …, 2019 - Elsevier
Background Deep brain stimulation for obsessive-compulsive disorder is a rapidly
developing treatment strategy for treatment-refractory patients. Both the exact target and …

Probabilistic sweet spots predict motor outcome for deep brain stimulation in Parkinson disease

TA Dembek, J Roediger, A Horn, P Reker… - Annals of …, 2019 - Wiley Online Library
Objective To investigate whether functional sweet spots of deep brain stimulation (DBS) in
the subthalamic nucleus (STN) can predict motor improvement in Parkinson disease (PD) …

Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia

A Horn, MM Reich, S Ewert, N Li… - Proceedings of the …, 2022 - National Acad Sciences
Dystonia is a debilitating disease with few treatment options. One effective option is deep
brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of …

[HTML][HTML] PaCER-A fully automated method for electrode trajectory and contact reconstruction in deep brain stimulation

A Husch, MV Petersen, P Gemmar, J Goncalves… - NeuroImage: Clinical, 2018 - Elsevier
Deep brain stimulation (DBS) is a neurosurgical intervention where electrodes are
permanently implanted into the brain in order to modulate pathologic neural activity. The …