It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …

Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …

The question of why people show individual differences in their behaviours and capacities
has intrigued researchers for centuries. Behaviour genetics offers us various methods to …

The molecular diversity of glia in the human hippocampus and their temporal dynamics over
the lifespan remain largely unknown. Here, we performed single-nucleus RNA sequencing …

The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

This meta-analysis investigated placebo responses in repetitive transcranial magnetic
stimulation treatment for depression, an area with limited systematic analysis. The initial …

Background Extensive evidence links higher body mass index (BMI) to higher odds of
depression in people of European ancestry. However, our understanding of the relationship …

Major depressive disorder (MDD) is a common mental disorder generally characterized by
symptoms associated with mood, pleasure and effectiveness in daily life activities. MDD is …

Using a longitudinal approach, we sought to define the interplay between genetic and
nongenetic factors in shaping vulnerability or resilience to COVID-19 pandemic stress, as …