A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they
have to be stored at (ultra) low temperatures. Understanding the root cause of the instability …

The remarkable impact of mRNA vaccines on mitigating disease and improving public
health has been amply demonstrated during the COVID-19 pandemic. Many new mRNA …

Lipid nanoparticle (LNP)-formulated mRNA vaccines were rapidly developed and deployed
in response to the SARS-CoV-2 pandemic. Due to the labile nature of mRNA, identifying …

Messenger RNA (mRNA) is a new class of therapeutic compounds. The current advances in
mRNA technology require the development of efficient analytical methods. In this work, we …

After thirty years of intensive research shaping and optimizing the technology, the approval
of the first mRNA-based formulation by the EMA and FDA in order to stop the COVID-19 …

Lipid encapsulated messenger RNA (LNP mRNA) has garnered a significant amount of
interest from the pharmaceutical industry and general public alike. This attention has been …

Highlights•mRNA therapeutics could represent the next generation drug for tissue
restoration in regenerative medicine.•Non-immunogenic mRNA can be generated by the …

Determination of phosphorothioate oligonucleotide purity and impurity profile is commonly
performed by ion-pairing reversed-phase liquid chromatography (IPRP) with a mobile phase …

Certain biomolecules have proven to be difficult to analyze by liquid chromatography (LC),
especially under certain chromatographic conditions. The separation of proteins in aqueous …

Therapeutic messenger RNAs (mRNAs) have emerged as powerful tools in the treatment of
complex diseases, especially for conditions that lack efficacious treatment. The successful …