[HTML][HTML] STING agonist promotes CAR T cell trafficking and persistence in breast cancer
Disclosures: N. Xu reported a patent to STING on CAR T therapy against solid tumor
pending. AC Robeson reported personal fees from Precision BioSciences, Inc. outside the …
pending. AC Robeson reported personal fees from Precision BioSciences, Inc. outside the …
A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
Switching macrophages from a pro-tumor type to an anti-tumor state is a promising strategy
for cancer immunotherapy. Existing agents, many derived from bacterial components, have …
for cancer immunotherapy. Existing agents, many derived from bacterial components, have …
Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8+ T-cell Response against Immunosuppressive Tumors
M Viitala, R Virtakoivu, S Tadayon, J Rannikko… - Clinical Cancer …, 2019 - AACR
Purpose: As foremost regulators of cancer-related inflammation and immunotherapeutic
resistance, tumor-associated macrophages have garnered major interest as …
resistance, tumor-associated macrophages have garnered major interest as …
MANF ameliorates DSS-induced mouse colitis via restricting Ly6ChiCX3CR1int macrophage transformation and suppressing CHOP-BATF2 signaling pathway
L Yang, W Shen, W Shao, Q Zhao, G Pang… - Acta Pharmacologica …, 2023 - nature.com
Mesencephalic astrocyte-derived neurotrophic factor (MANF), an endoplasmic reticulum
stress-inducible secreting protein, has evolutionarily conserved immune-regulatory function …
stress-inducible secreting protein, has evolutionarily conserved immune-regulatory function …
IFN-stimulated genes in zebrafish and humans define an ancient arsenal of antiviral immunity
JP Levraud, L Jouneau, V Briolat, V Laghi… - The Journal of …, 2019 - journals.aai.org
The evolution of the IFN system, the major innate antiviral mechanism of vertebrates,
remains poorly understood. According to the detection of type I IFN genes in cartilaginous …
remains poorly understood. According to the detection of type I IFN genes in cartilaginous …
Role of the basic leucine zipper transcription factor BATF2 in modulating immune responses and inflammation in health and disease
R van der Geest, JS Lee - Journal of Leukocyte Biology, 2024 - academic.oup.com
Basic leucine zipper transcription factor ATF-like 2 (BATF2) is a transcription factor that is
known to exhibit tumor-suppressive activity in cancer cells. Within recent years, however …
known to exhibit tumor-suppressive activity in cancer cells. Within recent years, however …
A novel immune checkpoint-related seven-gene signature for predicting prognosis and immunotherapy response in melanoma
M Tian, J Yang, J Han, J He, W Liao - International immunopharmacology, 2020 - Elsevier
Background New emergence of immunotherapy has significantly improved clinical outcome
of melanoma patients with advanced and metastatic diseases. We aimed to develop a gene …
of melanoma patients with advanced and metastatic diseases. We aimed to develop a gene …
Anti-tumor immunity by transcriptional synergy between TLR9 and STING activation
Agonists for TLR9 and stimulator of IFN genes (STING) offer therapeutic applications as both
anti-tumor agents and vaccine adjuvants, though their clinical applications are limited; the …
anti-tumor agents and vaccine adjuvants, though their clinical applications are limited; the …
m6A modification-mediated BATF2 suppresses metastasis and angiogenesis of tongue squamous cell carcinoma through inhibiting VEGFA
H Wen, J Tang, Y Cui, M Hou, J Zhou - Cell Cycle, 2023 - Taylor & Francis
The aim is to explore the underlying mechanism of basic leucine zipper ATF-like
transcription factor 2 (BATF2) in tongue squamous cell carcinoma (TSCC). The expression …
transcription factor 2 (BATF2) in tongue squamous cell carcinoma (TSCC). The expression …
BRD4 inhibition by AZD5153 promotes antitumor immunity via depolarizing M2 macrophages
X Li, Y Fu, B Yang, E Guo, Y Wu, J Huang… - Frontiers in …, 2020 - frontiersin.org
High-grade serous ovarian cancer (HGSOC), with its high recurrence rates, urges for
reasonable therapeutic strategies that can prolong overall survival. A tumor …
reasonable therapeutic strategies that can prolong overall survival. A tumor …