Abnormal vasculature is one of the most conspicuous traits of tumor tissue, largely
contributing to tumor immune evasion. The deregulation mainly arises from the potentiated …

Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …

Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

The midcycle surge of LH sets in motion interconnected networks of signaling cascades to
bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators …

Angiogenesis is a highly coordinated process of formation of new blood vessels from pre-
existing blood vessels. The process of development of the proper vascular network is a …

Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries
characterized by a local accumulation of cholesterol and non-resolving inflammation …

Anti-angiogenic therapy is one of the promising strategies for many types of solid cancers.
Bevacizumab (Avastin), a recombinant humanized monoclonal antibody of vascular …

Compared with traditional 2D adherent cell culture, 3D spheroidal cell aggregates, or
spheroids, are regarded as more physiological, and this technique has been exploited in the …

Smooth muscle cells (SMCs) possess remarkable phenotypic plasticity that allows rapid
adaptation to fluctuating environmental cues, including during development and progression …

Tie-1 and Tie-2 tyrosine kinase receptors are expressed specifically on vascular endothelial
cells and on a certain subtype of macrophages implicated in angiogenesis, thus, they have …