Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells

NSC Razali, KW Lam, NF Rajab, AR A. Jamal… - Scientific Reports, 2022 - nature.com
Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor
bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid …

Synthesis, conformational study and DFT analysis of novel nonlinear optically active 2r, 6c-diaryl-3t-methylpiperidin-4-one N-(2′-furoyl) hydrazones

V Meenatchi, SS Han - Journal of Molecular Structure, 2022 - Elsevier
A series of nonlinear optical (NLO) active 2-furoic acid hydrazide derivatives, 2r, 6c-diaryl-3t-
methylpiperidin-4-one N-(2′-furoyl) hydrazones (6–10), were synthesized. The structures of …

Investigation of the chemical and optical properties of halogen-substituted N-methyl-4-piperidone curcumin analogs by density functional theory calculations

AS Hutama, H Huang, YS Kurniawan - Spectrochimica Acta Part A …, 2019 - Elsevier
Abstract Halogen-substituted N-methyl-4-piperidone curcumin analog compounds were
studied for their molecular structure, molecular vibration analysis, natural bond orbital …

Expanding the Application of Alcohol Dehydrogenases in Pharmaceutical Chemistry: A Focus on Piperidone Synthesis

F Li, Y Wei, Y Du, Y Liang, Y Zheng, S Yuan… - …, 2024 - Wiley Online Library
Alcohol dehydrogenases (ADHs) have garnered recognition for their potential in the
synthesis of pivotal pharmaceutical compounds. However, their utilization in the context of …

Synthesis, in vitro anti-plasmodial potency, in-silico-cum-SPR binding with inhibition of Pf Pyridoxal synthase and rapid parasiticidal action by 3, 5-bis {(E) arylidene}-N …

SK Rokkam, M Yadav, M Joshi, AR Choudhury… - New Journal of …, 2021 - pubs.rsc.org
Twenty-five (Ia–Iu, IIa–IIb, IIIa, and IVa) diarylidene-N-methyl-4-piperidones (DANMPs) were
synthesized and characterized via UV, FT-IR, NMR, and MS while Id was characterized also …

Palladium decorated carbon nitride: A pragmatic catalyst for the construction of carbon-carbon double bonds in water

V Saravanan, P Lakshmanan, C Ramalingan - Journal of Molecular …, 2024 - Elsevier
Graphitic carbon nitride immobilized by palladium was synthesized through co-precipitation
method and characterized unequivocally by means of X-ray diffraction (XRD), infrared …

Synthesis, Characterization and Latent Fingerprints Detection of Novel Azo Dye Based on Curcumin and Its Pd (II) Complex

WD Kzar, HS Mohammed… - … Journal of Pure …, 2024 - qjps.researchcommons.org
Azo dye ligand (DCPAC) namely (1E, 6E)-4-((E)-(2, 5-dichlorophenyl) diazenyl)-1, 7-bis (4-
hydroxy-3-methoxyphenyl) hepta-1, 6-diene-3, 5-dione was prepared by coupling …

High anti-cancer activity, low animal toxicity, and structure activity relationships of curcumin analogs

SC Song, YL Mai, HH Shi, B Liao… - Letters in Drug Design & …, 2020 - ingentaconnect.com
Background: Inhibition of cancer cell growth and low in vivo toxicity are two important criteria
for the development of anti-cancer drugs. Curcumin is a promising candidate for developing …

Molecular Docking, Synthesis and In Vitro Antiplasmodium Assay of Monoketone Curcumin Analogous from 2-Chlorobenzaldehyde

CR Mustika, E Astuti, MID Mardjan - Indonesian Journal of … - dev.journal.ugm.ac.id
This research aimed to develop new curcumin analogous as antiplasmodium candidates.
Six curcumin analogous (1-6) were proposed and docked against three Plasmodium …

Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells

KM Chan, NSC Razali, KW Lam, NF Rajab, ARA Jamal… - 2022 - researchsquare.com
Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor
bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid …