Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

Steady progress over four decades toward understanding the pathogenesis and clinical
consequences of hepatic fibrosis has led to the expectation of effective antifibrotic drugs, yet …

The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …

Background A key task in single-cell RNA-seq (scRNA-seq) data analysis is to accurately
detect the number of cell types in the sample, which can be critical for downstream analyses …

Background Pro-inflammatory fibroblasts are critical for pathogenesis in rheumatoid arthritis,
inflammatory bowel disease, interstitial lung disease, and Sjögren's syndrome and represent …

Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …

Abstract Background Eosinophilic esophagitis (EoE) is a chronic immune-mediated rare
disease, characterized by esophageal dysfunctions. It is likely to be primarily activated by …

The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …

Detecting differentially expressed genes is important for characterizing subpopulations of
cells. In scRNA-seq data, however, nuisance variation due to technical factors like …

The extent splicing is regulated at single-cell resolution has remained controversial due to
both available data and methods to interpret it. We apply the SpliZ, a new statistical …