An inflammatory process in the central nervous system (CNS) is believed to play an
important role in the pathway leading to neuronal cell death in a number of …

HIV-associated dementia (HAD) is an important complication of the central nervous system
in patients who are infected with HIV-1. Although the incidence of HAD has markedly …

The nature of microglia fascinated many prominent researchers in the 19th and early 20th
centuries, and in a classic treatise in 1932, Pio del Rio-Hortega formulated a number of …

Macrophage/microglia (M∅) are the principal immune cells in the central nervous system
(CNS) concomitant with inflammatory brain disease and play a significant role in the host …

Infection with the human immunodeficiency virus-1 (HIV-1) can induce severe and
debilitating neurological problems that include behavioral abnormalities, motor dysfunction …

HIV can invade cells of the central nervous system (CNS) and cause progressive combined
cognitive and motor impairment in infected individuals. The cellular basis and mechanisms …

The numbers of immune-activated brain mononuclear phagocytes (MPs. affect the
progression of human immunodeficiency virus (HIV)-1-associated dementia (HAD). Such …

Approximately one third of adults and half of children with the acquired immunodeficiency
syndrome (AIDS) eventually have neurologic complications, which are directly attributable to …

l-Glutamate is the major excitatory neurotransmitter in the brain. Astrocytes maintain low
levels of synaptic glutamate by high-affinity uptake and defects in this function may lead to …

The blood-brain barrier (BBB) is compromised during progressive HIV-1 infection, but how
this occurs is incompletely understood. We studied the integrity of tight junctions (TJs) of …