X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …

Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …

Over the past decade, it has become clear that mammalian genomes encode thousands of
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …

Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a
multitude of pathways across species, but it remains challenging to understand which of …

Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The
evolutionary history of lncRNAs can provide insights into their functionality, but the absence …

Genomes of complex organisms encode an abundance and diversity of long noncoding
RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide variety of regulatory …

The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome
silencing induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the …

X chromosome inactivation and genomic imprinting are classic epigenetic processes that
cause disease when not appropriately regulated in mammals. Whereas X chromosome …

The koala, the only extant species of the marsupial family Phascolarctidae, is classified as
'vulnerable'due to habitat loss and widespread disease. We sequenced the koala genome …