The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Schizophrenia is a chronic and debilitating neuropsychiatric disorder affecting
approximately 1% of the world's population. This disease is associated with considerable …

The processing of rewards and losses are crucial to everyday functioning. Considerable
interest has been attached to investigating the anticipation and outcome phases of reward …

Negative symptoms have long been conceptualized as a core aspect of schizophrenia. They
play a key role in the functional outcome of the disorder, and their management represents a …

INTRODUCTION The drive to seek and experience reward is conserved across species and,
in mammals, involves interactions between subcortical dopaminergic systems and limbic …

This contribution offers a review, comprehensive to date, of a 15-year research program on
the broaden-and-build theory of positive emotions. Although centered on evidence that has …

Substance use disorders occur commonly in patients with schizophrenia and dramatically
worsen their overall clinical course. While the exact mechanisms contributing to substance …

Importance Abnormal reward processing is suggested to underlie the formation of psychotic
symptoms, likely driven by elevated ventral striatal (VS) dopamine levels. Functional …

We propose that schizophrenia involves a combination of decreased phasic dopamine
responses for relevant stimuli and increased spontaneous phasic dopamine release. Using …

This review integrates Fredrickson's broaden-and-build theory of positive emotions with
advances in affective neuroscience regarding plasticity in the neural circuitry of emotions to …