Small animal radiotherapy research platforms

F Verhaegen, P Granton… - Physics in Medicine & …, 2011 - iopscience.iop.org
Advances in conformal radiation therapy and advancements in pre-clinical radiotherapy
research have recently stimulated the development of precise micro-irradiators for small …

FLASH radiotherapy with photon beams

P Montay‐Gruel, S Corde, JA Laissue… - Medical …, 2022 - Wiley Online Library
Ultra‐high‐dose rate “FLASH” radiotherapy (FLASH‐RT) has been shown to drastically
reduce normal tissue toxicities while being as efficacious as conventional dose rate …

Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model

LML Smyth, JF Donoghue, JA Ventura, J Livingstone… - Scientific reports, 2018 - nature.com
Synchrotron radiation can facilitate novel radiation therapy modalities such as microbeam
radiation therapy (MRT) and high dose-rate synchrotron broad-beam radiation therapy …

Lattice or oxygen-guided radiotherapy: what if they converge? Possible future directions in the era of immunotherapy

G Ferini, V Valenti, A Tripoli, SI Illari, L Molino, S Parisi… - Cancers, 2021 - mdpi.com
Simple Summary Oxygen-guided radiotherapy is a new modality for cancer irradiation.
Spatially Fractionated Radiation Therapy allows the treatment of hypoxic tumor areas with …

Proton‐minibeam radiation therapy: a proof of concept

Y Prezado, GR Fois - Medical physics, 2013 - Wiley Online Library
Purpose: This Monte Carlo simulation work aims at studying a new radiotherapy approach
called proton‐minibeam radiation therapy (pMBRT). The main objective of this proof of …

Divide and conquer: spatially fractionated radiation therapy

Y Prezado - Expert reviews in molecular medicine, 2022 - cambridge.org
Spatially fractionated radiation therapy (SFRT) challenges some of the classical dogmas in
conventional radiotherapy. The highly modulated spatial dose distributions in SFRT have …

[HTML][HTML] Effects of microbeam radiation therapy on normal and tumoral blood vessels

A Bouchet, R Serduc, JA Laissue, V Djonov - Physica Medica, 2015 - Elsevier
Microbeam radiation therapy (MRT) is a new form of preclinical radiotherapy using quasi-
parallel arrays of synchrotron X-ray microbeams. While the deposition of several hundred …

Toward neuro-oncologic clinical trials of high-dose-rate synchrotron microbeam radiation therapy: first treatment of a spontaneous canine brain tumor

JF Adam, J Balosso, S Bayat, P Berkvens… - International Journal of …, 2022 - Elsevier
Purpose The high potential of microbeam radiation therapy (MRT) in improving tumor control
while reducing side effects has been shown by numerous preclinical studies. MRT offers a …

Tolerance to dose escalation in minibeam radiation therapy applied to normal rat brain: long-term clinical, radiological and histopathological analysis

Y Prezado, P Deman, P Varlet, G Jouvion… - Radiation …, 2015 - meridian.allenpress.com
The major limitation to reaching a curative radiation dose in radioresistant tumors such as
malignant gliomas is the high sensitivity to radiation and subsequent damage of the …

Microbeam radiotherapy—a novel therapeutic approach to overcome radioresistance and enhance anti-tumour response in melanoma

V Trappetti, JM Fazzari, C Fernandez-Palomo… - International journal of …, 2021 - mdpi.com
Melanoma is the deadliest type of skin cancer, due to its invasiveness and limited treatment
efficacy. The main therapy for primary melanoma and solitary organ metastases is wide …