Counter-regulatory renin–angiotensin system in cardiovascular disease
M Paz Ocaranza, JA Riquelme, L García… - Nature Reviews …, 2020 - nature.com
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …
The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - Elsevier
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …
from a binding site with unknown function to a firmly established major effector within the …
The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases
XC Li, J Zhang, JL Zhuo - Pharmacological research, 2017 - Elsevier
The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …
[HTML][HTML] Classical renin-angiotensin system in kidney physiology
MA Sparks, SD Crowley, SB Gurley… - Comprehensive …, 2014 - ncbi.nlm.nih.gov
The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …
sodium homeostasis. These actions are coordinated through integrated actions in the …
Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is a
devastating clinical syndrome with a high mortality rate (30–60%)(refs). Predisposing factors …
devastating clinical syndrome with a high mortality rate (30–60%)(refs). Predisposing factors …
Structural basis for selectivity and diversity in angiotensin II receptors
The angiotensin II receptors AT1R and AT2R serve as key components of the renin–
angiotensin–aldosterone system. AT1R has a central role in the regulation of blood …
angiotensin–aldosterone system. AT1R has a central role in the regulation of blood …
Cancer cachexia—pathophysiology and management
H Suzuki, A Asakawa, H Amitani, N Nakamura… - Journal of …, 2013 - Springer
About half of all cancer patients show a syndrome of cachexia, characterized by anorexia
and loss of adipose tissue and skeletal muscle mass. Cachexia can have a profound impact …
and loss of adipose tissue and skeletal muscle mass. Cachexia can have a profound impact …
Renin‐angiotensin system revisited
F Fyhrquist, O Saijonmaa - Journal of internal medicine, 2008 - Wiley Online Library
New components and functions of the renin‐angiotensin system (RAS) are still being
unravelled. The classical RAS as it looked in the middle 1970s consisted of circulating renin …
unravelled. The classical RAS as it looked in the middle 1970s consisted of circulating renin …
Angiotensin, thirst, and sodium appetite
JT Fitzsimons - Physiological reviews, 1998 - journals.physiology.org
Fitzsimons, JT Angiotensin, Thirst, and Sodium Appetite. Physiol. Rev. 78: 583–686, 1998.—
Angiotensin (ANG) II is a powerful and phylogenetically widespread stimulus to thirst and …
Angiotensin (ANG) II is a powerful and phylogenetically widespread stimulus to thirst and …