Berberine attenuated proliferation, invasion and migration by targeting the AMPK/HNF4α/WNT5A pathway in gastric carcinoma

Q Hu, L Li, X Zou, L Xu, P Yi - Frontiers in pharmacology, 2018 - frontiersin.org
Background: Recent epidemiologic studies have found that patients with diabetes have a
higher risk of gastric cancer (GC), and the long-term use of metformin is associated with a …

Comparative pathobiology of canine and human prostate cancer: state of the art and future directions

EP Nascente, RL Amorim, CE Fonseca-Alves… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer (PC) is one of the main types of cancer that affects the
male population worldwide. In recent decades, there has been a significant evolution in the …

miR-541-3p enhances the radiosensitivity of prostate cancer cells by inhibiting HSP27 expression and downregulating β-catenin

Z He, F Shen, P Qi, Z Zhai, Z Wang - Cell Death Discovery, 2021 - nature.com
Abstract Heat shock protein 27 (HSP27), a regulator of cell survival, can enhance the
resistance of cancer cells to radiotherapy. As microRNA-541-3p (miR-541-3p) was recently …

Molecular Similarities and Differences between Canine Prostate Cancer and Human Prostate Cancer Variants

DM Vasilatis, CA Lucchesi, PM Ghosh - Biomedicines, 2023 - mdpi.com
Dogs are one of few species that naturally develop prostate cancer (PCa), which clinically
resembles aggressive, advanced PCa in humans. Moreover, PCa-tumor samples from dogs …

An RNA-Seq-based framework for characterizing canine prostate cancer and prioritizing clinically relevant biomarker candidate genes

H Thiemeyer, L Taher, JT Schille, EM Packeiser… - International journal of …, 2021 - mdpi.com
Prostate cancer (PCa) in dogs is a highly malignant disease akin to its human counterpart. In
contrast to the situation in humans, multi-gene approaches facilitating risk stratification of …

Caveolin‐1‐Knockout Mouse as a Model of Inflammatory Diseases

E Codrici, L Albulescu, ID Popescu… - Journal of …, 2018 - Wiley Online Library
Caveolin‐1 (CAV1) is the scaffold protein of caveolae, which are minute invaginations of the
cell membrane that are involved in endocytosis, cell signaling, and endothelial‐mediated …

Lactobacillus fermentum ZS09 Mediates Epithelial–Mesenchymal Transition (EMT) by Regulating the Transcriptional Activity of the Wnt/β-Catenin Signalling Pathway …

J Liu, X Chen, X Zhou, R Yi, Z Yang… - Journal of Inflammation …, 2021 - Taylor & Francis
Objective The epithelial–mesenchymal transition (EMT) pathway can mediate tumour
migration, and the occurrence of EMT is closely related to the Wnt/β-catenin signalling …

Comprehensive genomic profiling of androgen-receptor-negative canine prostate cancer

R Laufer-Amorim, CE Fonseca-Alves… - International Journal of …, 2019 - mdpi.com
Canine carcinomas have been considered natural models for human diseases; however,
the genomic profile of canine prostate cancers (PCs) has not been explored. In this study, 14 …

Junctional complexes of the blood-testis barrier in the Japanese quail (Coturnix Coturnix japonica)

RA Molele, MIA Ibrahim, M Zakariah, MAA Mahdy… - Acta …, 2022 - Elsevier
This study investigated the developmental changes in the adherens junctions, gap junctions,
as well as tight junctions forming the blood-testis barrier (BTB) in Japanese quail (Coturnix …

Anatomy, histology, and physiology of the canine prostate gland

AF Leis-Filho, CE Fonseca-Alves - Veterinary anatomy and …, 2018 - books.google.com
The prostate gland is the only male accessory gland in dogs and is responsible for secreting
the prostatic fluid. Morphologically, the canine prostate gland lacks differentiation into zones …