The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-
related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's …

Deposition of amyloid plaques in the brains of Alzheimer's disease (AD) patients is a
hallmark of the disease. AD plaques consist primarily of the beta-amyloid (Aβ) peptide but …

Protein homeostasis, or proteostasis, is a combination of cellular processes that govern
protein quality control, namely, protein translation, folding, processing, and degradation …

Abstract αB-Crystallin (αB-Cry) is expressed in many tissues, and mutations in this protein
are linked to various diseases, including cataracts, Alzheimer's disease, Parkinson's …

The dysfunction of the proteostasis network is a molecular hallmark of neurodegenerative
diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and …

Over the past decade, the greatest promise for treating severe and currently incurable
systemic and neurodegenerative diseases has turned to agents capable of effectively …

Synucleinopathies are neurodegenerative diseases characterized by the presence of
intracellular deposits containing the protein alpha-synuclein (aSYN) within patients' brains. It …

The process of protein misfolding and aggregation is associated with various cytotoxic
effects. Understanding how this phenomenon is regulated by the protein homeostasis …

Post-translational modifications (PTMs) of alpha-synuclein (α-syn) can alter protein
aggregation propensity to affect α-syn oligomer and fibril formation. The inflammatory …