Advances in the development of new biomarkers for Alzheimer's disease

TO Klyucherev, P Olszewski, AA Shalimova… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …

Spectral-domain OCT measurements in Alzheimer's disease: a systematic review and meta-analysis

VTT Chan, Z Sun, S Tang, LJ Chen, A Wong, CC Tham… - Ophthalmology, 2019 - Elsevier
Topic OCT is a noninvasive tool to measure specific retinal layers in the eye. The
relationship of retinal spectral-domain (SD) OCT measurements with Alzheimer's disease …

[HTML][HTML] Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease

Y Koronyo, D Biggs, E Barron, DS Boyer, JA Pearlman… - JCI insight, 2017 - ncbi.nlm.nih.gov
BACKGROUND. Noninvasive detection of Alzheimer's disease (AD) with high specificity and
sensitivity can greatly facilitate identification of at-risk populations for earlier, more effective …

[HTML][HTML] Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: a review and synthesis

CY Santos, PJ Snyder, WC Wu, M Zhang… - Alzheimer's & Dementia …, 2017 - Elsevier
As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Retinal microvascular and neurodegenerative changes in Alzheimer's disease and mild cognitive impairment compared with control participants

SP Yoon, DS Grewal, AC Thompson, BW Polascik… - Ophthalmology …, 2019 - Elsevier
Purpose Evaluate and compare the retinal microvasculature in the superficial capillary
plexus (SCP) in Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively …

Retinal imaging in Alzheimer's and neurodegenerative diseases

PJ Snyder, J Alber, C Alt, LJ Bain… - Alzheimer's & …, 2021 - Wiley Online Library
In the last 20 years, research focused on developing retinal imaging as a source of potential
biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased …

Ocular indicators of Alzheimer's: exploring disease in the retina

NJ Hart, Y Koronyo, KL Black… - Acta neuropathologica, 2016 - Springer
Although historically perceived as a disorder confined to the brain, our understanding of
Alzheimer's disease (AD) has expanded to include extra-cerebral manifestation, with …

Hypertensive eye disease

CY Cheung, V Biousse, PA Keane… - Nature Reviews …, 2022 - nature.com
Hypertensive eye disease includes a spectrum of pathological changes, the most well
known being hypertensive retinopathy. Other commonly involved parts of the eye in …

Past, present and future role of retinal imaging in neurodegenerative disease

AH Kashani, S Asanad, JW Chan, MB Singer… - Progress in retinal and …, 2021 - Elsevier
Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts
of information about the structure, function and molecular composition of retinal tissue in …

Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances

VB Gupta, N Chitranshi, J den Haan, M Mirzaei… - Progress in retinal and …, 2021 - Elsevier
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …