Systemic autoimmune diseases are a group of disorders characterized by a failure in self-
tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these …

Neutrophils play an established role in host defense and in killing invading microorganisms.
Although neutrophils are traditionally considered in the context of their antibacterial …

Based on studies in mouse tumor models, granulocytes appear to play a tumor-promoting
role. However, there are limited data about the phenotype and function of tumor-associated …

TGF-β blockade significantly slows tumor growth through many mechanisms, including
activation of CD8+ T cells and macrophages. Here, we show that TGF-β blockade also …

It is becoming increasingly clear that tumor-associated neutrophils (TANs) play an important
role in cancer biology, through direct impact on tumor growth and by recruitment of other …

Abstract The anti-granulocyte receptor-1 (Gr-1) mAb, RB6-8C5, has been used extensively
to deplete neutrophils in mice and to investigate the role of these cells in host defense. RB6 …

Macrophages in granulomas are both antimycobacterial effector and host cell for
Mycobacterium tuberculosis, yet basic aspects of macrophage diversity and function within …

The etiopathogenesis of systemic lupus erythematosus (SLE), a clinically heterogeneous
multisystemic syndrome that derives its name from the initial characterization of facial …

Although the signals that control neutrophil migration from the blood to sites of infection have
been well characterized, little is known about their migration patterns within lymph nodes or …

It was originally thought that a cell's major histocompatibility complex (MHC) class I
molecules presented peptides derived exclusively from proteins synthesized by the cell …