Endothelial dysfunction and vascular disease–a 30th anniversary update

PM Vanhoutte, H Shimokawa, M Feletou… - Acta …, 2017 - Wiley Online Library
The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Polyphenols and glycemic control

Y Kim, JB Keogh, PM Clifton - Nutrients, 2016 - mdpi.com
Growing evidence from animal studies supports the anti-diabetic properties of some dietary
polyphenols, suggesting that dietary polyphenols could be one dietary therapy for the …

[HTML][HTML] Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study …

HD Sesso, JAE Manson, AK Aragaki, PM Rist… - The American journal of …, 2022 - Elsevier
Background Cocoa extract is a source of flavanols that favorably influence vascular risk
factors in small and short-term trials, yet effects on clinical cardiovascular events are …

Dietary (poly) phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases

D Del Rio, A Rodriguez-Mateos… - Antioxidants & redox …, 2013 - liebertpub.com
Human intervention trials have provided evidence for protective effects of various (poly)
phenol-rich foods against chronic disease, including cardiovascular disease …

Dietary anti-aging polyphenols and potential mechanisms

J Luo, H Si, Z Jia, D Liu - Antioxidants, 2021 - mdpi.com
For years, the consumption of a diet rich in fruits and vegetables has been considered
healthy, increasing longevity, and decreasing morbidities. With the assistance of basic …

Current evidence on the effect of dietary polyphenols intake on chronic diseases

C Costa, A Tsatsakis, C Mamoulakis, M Teodoro… - Food and Chemical …, 2017 - Elsevier
Polyphenols are secondary metabolites of plants. They comprise several antioxidant
compounds and they are generally considered to be involved in the defense against human …

[HTML][HTML] Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging …

D Mastroiacovo, C Kwik-Uribe, D Grassi… - The American journal of …, 2015 - Elsevier
Background: Recent evidence has indicated that flavanol consumption may have many
health benefits in humans, including improved cognitive activities. Objective: The aim was to …

Polyphenols and human health: prevention of disease and mechanisms of action

D Vauzour, A Rodriguez-Mateos, G Corona… - Nutrients, 2010 - mdpi.com
Polyphenols are found ubiquitously in plants and their regular consumption has been
associated with a reduced risk of a number of chronic diseases, including cancer …

[HTML][HTML] Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials

L Hooper, C Kay, A Abdelhamid, PA Kroon… - The American journal of …, 2012 - Elsevier
Background: There is substantial interest in chocolate and flavan-3-ols for the prevention of
cardiovascular disease (CVD). Objective: The objective was to systematically review the …

Role of insulin resistance in endothelial dysfunction

R Muniyappa, JR Sowers - Reviews in Endocrine and Metabolic Disorders, 2013 - Springer
Insulin resistance is frequently associated with endothelial dysfunction and has been
proposed to play a major role in cardiovascular diseases. Insulin exerts pro-and anti …