▪ Abstract Aminoacyl-tRNAs are substrates for translation and are pivotal in determining how
the genetic code is interpreted as amino acids. The function of aminoacyl-tRNA synthesis is …

The aminoacyl‐tRNA synthetases are prominently known for their classic function in the first
step of protein synthesis, where they bear the responsibility of setting the genetic code. Each …

Protein kinase GCN2 is a multidomain protein that contains a region homologous to histidyl-
tRNA synthetases juxtaposed to the kinase catalytic moiety. Previous studies have shown …

The crystal structure of the RNA-binding domain of the small nuclear ribonucleoprotein U1A
bound to a 21-nucleotide RNA hairpin has been determined at 1.92 Å resolution. The ten …

The coiled coil is arguably the simplest protein-structure motif and probably the most
ubiquitous facilitator of protein-protein interactions. Coiled coils comprise two or more α …

The crystal structure of Thermus thermophilus seryl-transfer RNA synthetase, a class 2
aminoacyl-tRNA synthetase, complexed with a single tRNASer molecule was solved at 2.9 Å …

An RNA has been selected that rapidly aminoacylates its 2′(3′) terminus when provided
with phenylalanyl-adenosine monophosphate. That is, the RNA accelerates the same …

After synthesis and processing in the nucleus, mature transfer RNAs (tRNAs) are exported to
the cytoplasm in a Ran· guanosine triphosphate–dependent manner. Export of defective or …

Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant
microorganisms. Numerous natural nucleosides and their synthetically modified analogues …

The molecular-replacement method has been extended to locate molecules and their
fragments in an electron-density map. The approach is based on a new spherically …