Recent trends in biocatalysis

D Yi, T Bayer, CPS Badenhorst, S Wu… - Chemical Society …, 2021 - pubs.rsc.org
Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Mechanism-based design of efficient PET hydrolases

R Wei, G von Haugwitz, L Pfaff, J Mican… - ACS …, 2022 - ACS Publications
Polyethylene terephthalate (PET) is the most widespread synthetic polyester, having been
utilized in textile fibers and packaging materials for beverages and food, contributing …

Machine‐Learning‐Assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes

J Zhuang, AC Midgley, Y Wei, Q Liu, D Kong… - Advanced …, 2024 - Wiley Online Library
Nanozymes are nanomaterials that exhibit enzyme‐like biomimicry. In combination with
intrinsic characteristics of nanomaterials, nanozymes have broad applicability in materials …

SoluProt: prediction of soluble protein expression in Escherichia coli

J Hon, M Marusiak, T Martinek, A Kunka… - …, 2021 - academic.oup.com
Motivation Poor protein solubility hinders the production of many therapeutic and industrially
useful proteins. Experimental efforts to increase solubility are plagued by low success rates …

Looking back: a short history of the discovery of enzymes and how they became powerful chemical tools

CM Heckmann, F Paradisi - ChemCatChem, 2020 - Wiley Online Library
Enzymatic approaches to challenges in chemical synthesis are increasingly popular and
very attractive to industry given their green nature and high efficiency compared to traditional …

[HTML][HTML] Automating the design-build-test-learn cycle towards next-generation bacterial cell factories

N Gurdo, DC Volke, D McCloskey, PI Nikel - New Biotechnology, 2023 - Elsevier
Automation is playing an increasingly significant role in synthetic biology. Groundbreaking
technologies, developed over the past 20 years, have enormously accelerated the …

Machine learning modeling of family wide enzyme-substrate specificity screens

S Goldman, R Das, KK Yang… - PLoS computational …, 2022 - journals.plos.org
Biocatalysis is a promising approach to sustainably synthesize pharmaceuticals, complex
natural products, and commodity chemicals at scale. However, the adoption of biocatalysis …

Accelerating biocatalysis discovery with machine learning: a paradigm shift in enzyme engineering, discovery, and design

B Markus, K Andreas, K Arkadij, L Stefan, O Gustav… - ACS …, 2023 - ACS Publications
Emerging computational tools promise to revolutionize protein engineering for biocatalytic
applications and accelerate the development timelines previously needed to optimize an …

A nonconventional archaeal fluorinase identified by in silico mining for enhanced fluorine biocatalysis

I Pardo, D Bednar, P Calero, DC Volke… - ACS …, 2022 - ACS Publications
Fluorinases, the only enzymes known to catalyze the transfer of fluorine to an organic
molecule, are essential catalysts for the biological synthesis of valuable organofluorines …

FireProtASR: A Web Server for Fully Automated Ancestral Sequence Reconstruction

M Musil, RT Khan, A Beier, J Stourac… - Briefings in …, 2021 - academic.oup.com
There is a great interest in increasing proteins' stability to widen their usability in numerous
biomedical and biotechnological applications. However, native proteins cannot usually …