Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages

L Ni, Z Lin, S Hu, Y Shi, Z Jiang, J Zhao, Y Zhou… - Biochemical …, 2022 - Elsevier
Osteoarthritis (OA) is a progressive joint disease characterized by the degradation and
destruction of articular cartilage, which is involved with pathological microenvironmental …

Application of PEEK in total cervical disc arthroplasty: A review

N Chikkanna, S Krishnapillai, S Kumar… - Materials Today …, 2023 - Elsevier
Cervical disc arthroplasty (CDA) is a surgical procedure where a degenerated or damaged
cervical disc is removed and replaced with an artificial disc in levels C3/4, C4/5, C5/6, and …

New therapeutic targets for osteoarthritis pain

DA Walsh, J Stocks - SLAS DISCOVERY: Advancing Life …, 2017 - journals.sagepub.com
Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as
emotional distress. While total joint replacement is one of the most effective treatments …

Articular cartilage-and synoviocyte-binding poly (ethylene glycol) nanocomposite microgels as intra-articular drug delivery vehicles for the treatment of osteoarthritis

LM Mancipe Castro, A Sequeira… - ACS biomaterials …, 2020 - ACS Publications
Intra-articular (IA) injection is an attractive route of administration for the treatment of
osteoarthritis (OA). However, free drugs injected into the joint space are rapidly cleared and …

[HTML][HTML] Toward understanding the role of cartilage particulates in synovial inflammation

AM Silverstein, RM Stefani, E Sobczak, EL Tong… - Osteoarthritis and …, 2017 - Elsevier
Objective Arthroscopy with lavage and synovectomy can remove tissue debris from the joint
space and the synovial lining to provide pain relief to patients with osteoarthritis (OA). Here …

A novel cartilage fragments stimulation model revealed that macrophage inflammatory response causes an upregulation of catabolic factors of chondrocytes in vitro

M Hamasaki, MA Terkawi, T Onodera, K Homan… - Cartilage, 2021 - journals.sagepub.com
Objective Osteoarthritis is a progressive joint disease characterized by cartilage degradation
and synovial inflammation. Presence of cartilage fragments in the joint due to degradation of …

Comparison of wear on articular cartilage by titanium alloy, ultra-high-molecular-weight polyethylene, and carbon fibre reinforced polyether-ether-ketone: a pilot study

R Sun, K Vats, JJ Baptiste, S Adeeb, N Jomha… - Medical Engineering & …, 2023 - Elsevier
Artificial implant materials may articulate against native articular cartilage in certain clinical
scenarios and the selection of an implant material that results in the least wear on articular …

MSCs derived membrane coating nanoparticles targeted delivery itaconic acid to regulate M1 macrophage pyroptosis for osteoarthritis therapy

Y Dong, J Wan, H Xiao, J Wang, X Yu, Y Liu, S Lei… - Applied Materials …, 2024 - Elsevier
Osteoarthritis (OA) is a common chronic inflammatory disorder and a major cause of
disability. Previous studies have shown that M1 macrophages play an important role in …

Biomechanical effects of fixed-bearing femoral prostheses with different coronal positions in medial unicompartmental knee arthroplasty

P Ma, A Muheremu, S Zhang, Q Zheng, W Wang… - Journal of Orthopaedic …, 2022 - Springer
Background To study the biomechanical effects of femoral prostheses at different coronal
positions using finite element analysis and provide a clinical reference for unicompartmental …

Hygrothermal aging effects on tribological and mechanical behaviors of mollusc shell-reinforcement UHMWPE biocomposites

B Sidia, W Bensalah - Journal of Thermoplastic Composite …, 2023 - journals.sagepub.com
The effect of hygrothermal aging on the tribological and mechanical behaviors of UHMWPE
biocomposites reinforced with different weight fractions of mollusc shell (MS) particles was …