A systematic review of clinical studies on variable proton Relative Biological Effectiveness (RBE)

TSA Underwood, AL McNamara, A Appelt… - Radiotherapy and …, 2022 - Elsevier
Recently, a number of clinical studies have explored links between possible Relative
Biological Effectiveness (RBE) elevations and patient toxicities and/or image changes …

A systematic review of let-guided treatment plan optimisation in proton therapy: identifying the current state and future needs

M McIntyre, P Wilson, P Gorayski, E Bezak - Cancers, 2023 - mdpi.com
Simple Summary The increasing global demand and accessibility for proton beam therapy
has been fueled by its recognised clinical benefits over traditional radiotherapy, primarily its …

State-of-the-art and potential of experimental microdosimetry in ion-beam therapy

G Magrin, H Palmans, M Stock, D Georg - Radiotherapy and Oncology, 2023 - Elsevier
In radiotherapy, radiation-quality should be an expression of the biological and physical
characteristics of ionizing radiation such as spatial distribution of ionization or energy …

[HTML][HTML] Novel unconventional radiotherapy techniques: Current status and future perspectives–Report from the 2nd international radiation oncology online seminar

S Tubin, MC Vozenin, Y Prezado, M Durante… - Clinical and …, 2023 - Elsevier
Novel unconventional radiotherapy techniques: Current status and future perspectives –
Report from the 2nd international radiation oncology online seminar - ScienceDirect Skip to …

Increased relative biological effectiveness and periventricular radiosensitivity in proton therapy of glioma patients

J Eulitz, EGC Troost, L Klünder, F Raschke… - Radiotherapy and …, 2023 - Elsevier
Purpose Currently, there is an intense debate on variations in intra-cerebral radiosensitivity
and relative biological effectiveness (RBE) in proton therapy of primary brain tumours. Here …

Passive SOBP generation from a static proton pencil beam using 3D-printed range modulators for FLASH experiments

F Horst, E Beyreuther, E Bodenstein, S Gantz… - Frontiers in …, 2023 - frontiersin.org
The University Proton Therapy facility in Dresden (UPTD), Germany, is equipped with an
experimental room with a beamline providing a static pencil beam. High proton beam …

NRG oncology white paper on the relative biological effectiveness in proton therapy

H Paganetti, CB Simone II, WR Bosch… - International Journal of …, 2024 - Elsevier
This position paper, led by the NRG Oncology Particle Therapy Work Group, focuses on the
concept of relative biologic effect (RBE) in clinical proton therapy, with the goal of providing …

The dirty and clean dose concept: towards creating proton therapy treatment plans with a photon‐like dose response

L Heuchel, C Hahn, J Ödén, E Traneus, J Wulff… - Medical …, 2024 - Wiley Online Library
Background Applying tolerance doses for organs at risk (OAR) from photon therapy
introduces uncertainties in proton therapy when assuming a constant relative biological …

Optically stimulated luminescence detectors for dosimetry and LET measurements in light ion beams

JB Christensen, ID Muñoz, N Bassler… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. This work investigates the use of Al 2 O 3: C and Al 2 O 3: C, Mg optically
stimulated luminescence (OSL) detectors to determine both the dose and the radiation …

[HTML][HTML] Status of LET assessment with active and passive detectors in ion beams

JB Christensen, ID Muñoz, P Bilski, V Conte… - Radiation …, 2024 - Elsevier
This review explores current experimental methods for determining the radiation quality in
ion beams. In this context, radiation quality is commonly evaluated using the averaged linear …