Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout/mutated mice
SY Jiao, YH Yang, SR Chen - Human reproduction update, 2021 - academic.oup.com
BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
Mechanisms of ovarian aging in women: a review
X Wang, L Wang, W Xiang - Journal of Ovarian Research, 2023 - Springer
Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …
Molecular genetics of premature ovarian insufficiency
Premature ovarian insufficiency (POI) is highly heterogeneous in genetic etiology. Yet
identifying causative genes has been challenging with candidate gene approaches. Recent …
identifying causative genes has been challenging with candidate gene approaches. Recent …
Genetics of human female infertility
SA Yatsenko, A Rajkovic - Biology of reproduction, 2019 - academic.oup.com
About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …
term. Female factors alone account for at least 35% of all infertility cases and comprise a …
Genetics of azoospermia
Azoospermia affects 1% of men, and it can be due to:(i) hypothalamic-pituitary
dysfunction,(ii) primary quantitative spermatogenic disturbances,(iii) urogenital duct …
dysfunction,(ii) primary quantitative spermatogenic disturbances,(iii) urogenital duct …
Genetics of ovarian insufficiency and defects of folliculogenesis
MM França, BB Mendonca - … practice & research Clinical endocrinology & …, 2022 - Elsevier
Primary ovarian insufficiency (POI) is determined by exhaustion of follicles in the ovaries,
which leads to infertility before the age of 40 years. It is characterized by a strong familial …
which leads to infertility before the age of 40 years. It is characterized by a strong familial …
[HTML][HTML] Recent advances in understanding primary ovarian insufficiency
V Wesevich, AN Kellen, L Pal - F1000Research, 2020 - ncbi.nlm.nih.gov
Primary ovarian insufficiency (POI) is an uncommon yet devastating occurrence that results
from a premature depletion of the ovarian pool of primordial follicles. Our understanding of …
from a premature depletion of the ovarian pool of primordial follicles. Our understanding of …
Genetic landscape of a large cohort of Primary Ovarian Insufficiency: New genes and pathways and implications for personalized medicine
A Heddar, C Ogur, S Da Costa, I Braham… - …, 2022 - thelancet.com
Summary Background Primary Ovarian Insufficiency (POI), a public health problem, affects 1-
3.7% of women under 40 yielding infertility and a shorter lifespan. Most causes are …
3.7% of women under 40 yielding infertility and a shorter lifespan. Most causes are …
Meiosis interrupted: the genetics of female infertility via meiotic failure
Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …
Premature ovarian insufficiency
SM McGlacken-Byrne, GS Conway - Best Practice & Research Clinical …, 2022 - Elsevier
The natural lifespan of the ovary is occasionally interrupted by pathological processes; some
are known, but many are unknown. Premature ovarian insufficiency (POI) can be a …
are known, but many are unknown. Premature ovarian insufficiency (POI) can be a …