Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …

Wnt/β-catenin signaling is a highly conserved pathway that regulates cell proliferation,
differentiation, apoptosis, stem cell self-renewal, tissue homeostasis, and wound healing …

Targeted protein degradation has emerged as a new paradigm to manipulate cellular
proteostasis. Proteolysis-targeting chimeras (PROTACs) are bifunctional small molecules …

Establishing a valid in vitro model to represent tumor heterogeneity and biology is critical but
challenging. Tumor organoids are self‐assembled three‐dimensional cell clusters which are …

Since the recognition that mutations in components of the Wnt–β-catenin pathway underlie
some human cancers, considerable attention has been dedicated to developing therapeutic …

R-spondin (RSPO) proteins amplify Wnt signaling and stimulate regeneration in a variety of
tissues. To repair tissue in a tissue-specific manner, tissue-targeted RSPO mimetic …

Selective and precise activation of signaling transduction cascades is key for cellular
reprogramming and tissue regeneration. However, the development of small-or large …

Wnt proteins are secreted morphogens that play critical roles in embryonic development,
stem cell proliferation, self-renewal, tissue regeneration and remodeling in adults. While …

WNT signaling, essential for many aspects of development, is among the most commonly
altered pathways associated with human disease. While initially studied in cancer …

Simple Summary One Health is a concept that describes the interplay between humans,
animals, and the environment. This interaction is becoming increasingly important as …