Amidst the global shortfalls in blood supply, storage limitations of donor blood and the
availability of potential blood substitutes for transfusion applications, society has pivoted …

Oxygen therapeutics has a range of applications in transfusion medicine and disease
treatment. Synthetic molecules and all‐natural or semisynthetic hemoglobin‐based oxygen …

Introduction: The demand for red blood cells (RBCs) is on the rise due to the increasing
diagnosis of chronic diseases such as sickle cell anemia, malaria, and thalassemia. Despite …

Hemorrhagic shock leads to intravasal volume deficiency, tissue hypoxia, and cellular
anaerobic metabolism. Hemoglobin (Hb) could deliver oxygen for hypoxic tissues but is …

In contrast to mammalian hemoglobins, annelids do not have red blood cells and transport
oxygen via erythrocruorins (Ecs), a unique type of extracellular hemoglobin that is constantly …

Oxygen therapeutics have a range of applications in transfusion medicine and disease
treatment. Synthetic molecules and all-natural or semi-synthetic hemoglobin-based oxygen …

Adenosine triphosphate (ATP) has a high affinity for the organic phosphate binding site of
hemoglobin (Hb), affecting the affinity for oxygen. Periodate-oxidized-ATP (oATP) behaves …

Hemoglobin‐based oxygen carriers (HBOCs) have been proposed and tested for several
decades for the treatment of hemorrhage. We have previously proposed replacing …