COVID-19 is characterized by dysregulated thrombosis and coagulation that can increase
mortality in patients. Platelets are fast responders to pathogen presence, alerting the …

In the broad range of human diseases, thrombo-inflammation appears as a clinical
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …

Abstract S100A8/A9, also known as “calprotectin” or “MRP8/14,” is an alarmin primarily
secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic …

Despite the emergence of high quality randomized trial data with the use of antithrombotic
agents to reduce the risk of thromboembolism, end‐organ failure, and possibly mortality in …

Several independent lines of evidence suggest that megakaryocytes are dysfunctional in
severe COVID-19. Herein, we characterized peripheral circulating megakaryocytes in a …

Immunothrombosis—immune-mediated activation of coagulation—is protective against
pathogens, but excessive immunothrombosis can result in pathological thrombosis and …

SARS-CoV-2 is a novel coronavirus responsible for the COVID-19 pandemic. Its high
pathogenicity is due to SARS-CoV-2 spike protein (S protein) contacting host-cell receptors …

Background The current COVID-19 pandemic from the human pathogenic virus SARS-CoV-
2 has resulted in a major health hazard globally. The morbidity and transmission modality of …

Background: SARS-CoV-2 is associated with an increased risk of venous and arterial
thrombosis, but the underlying mechanism is still unclear. Methods: We performed a cross …

Platelets are very abundant in the blood, where they play a role in hemostasis, inflammation,
and immunity. When activated, platelets undergo a conformational change that allows the …