Anti-tumor immune potentiation targets-engineered nanobiotechnologies: design principles and applications

R Jiao, X Lin, Q Zhang, Y Zhang, W Qin, Q Yang… - Progress in Materials …, 2024 - Elsevier
Combined therapeutic strategies hold promises in augmenting antigen release to enhance
anti-tumor immunity, which have garnered attention in numerous scholarly reviews. Beyond …

Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy

Y Xi, L Chen, J Tang, B Yu, W Shen… - Immunological …, 2024 - Wiley Online Library
Immunogenic cell death (ICD) is a unique mode of cell death, which can release
immunogenic damage‐associated molecular patterns (DAMPs) and tumor‐associated …

Bioactive phosphorus dendrimers as a Universal protein delivery system for enhanced anti-inflammation therapy

H Sun, M Zhan, A Karpus, Y Zou, J Li, S Mignani… - ACS …, 2024 - ACS Publications
Nanocarrier-based cytoplasmic protein delivery offers opportunities to develop protein
therapeutics; however, many delivery systems are positively charged, causing severe toxic …

Redox‐Responsive Dendrimer Nanogels Enable Ultrasound‐Enhanced Chemoimmunotherapy of Pancreatic Cancer via Endoplasmic Reticulum Stress Amplification …

G Zhang, M Zhan, C Zhang, Z Wang, H Sun… - Advanced …, 2023 - Wiley Online Library
Developing a multifunctional nanoplatform to achieve efficient theranostics of tumors
through multi‐pronged strategies remains to be challenging. Here, the design of the …

An Adhesive Immune‐Stimulating Multifunctional Hydrogel for Potent Tumor Chemoimmunotherapy and Postoperative Wound Healing Promotion

T Wang, J Ding, S Liang, Z Lin, J Yang… - Advanced Functional …, 2024 - Wiley Online Library
Surgical excision is the first choice for clinical cancer therapy. However, major challenges,
such as postoperative tumor recurrence and unsatisfactory wound healing after surgery …

Cancer Immunotherapy Based on Cell Membrane‐Coated Nanocomposites Augmenting cGAS/STING Activation by Efferocytosis Blockade

Z Chen, Z Li, H Huang, G Shen, Y Ren, X Mao, L Wang… - Small, 2023 - Wiley Online Library
Innate immunity triggered by the cGAS/STING pathway has the potential to improve cancer
immunotherapy. Previously, the authors reported that double‐stranded DNA (dsDNA) …

Dual-targeting nanozyme combined with aPD-L1-based immunotherapy for combating cancer recurrence and metastasis

L Tang, Y Cao, Y Yin, H Liu, J Feng, C Fu, Q Zhao… - Materials Today, 2024 - Elsevier
The heterogeneity of tumor microenvironment (TME) and existence of cancer stem cells
(CSCs) severely impede the therapeutic efficacy of current anti-tumor treatments, which is …

Poly (alkylideneamine) dendrimer nanogels codeliver drug and nucleotide to alleviate anticancer drug resistance through immunomodulation

Y Gao, Z Ouyang, G Li, Q Yu, W Dai… - ACS Materials …, 2024 - ACS Publications
The development of drug delivery strategies with the desired immunomodulation effects to
alleviate tumor drug resistance remains a challenge. Herein, low-generation poly …

Doxorubicin-loaded platelet decoys for enhanced chemoimmunotherapy against triple-negative breast cancer in mice model

H Dong, M Gao, L Lu, R Gui, Y Fu - International Journal of …, 2023 - Taylor & Francis
Introduction Triple-negative breast cancer (TNBC) is a highly aggressive subtype with a poor
prognosis. Current single-agent checkpoint therapy has limited effectiveness in TNBC …

Paclitaxel Prodrug Enables Glutathione Depletion to Boost Cancer Treatment

B Zhang, S Zhou, S Lu, X Xiang, X Yao, W Lei, Q Pei… - ACS …, 2024 - ACS Publications
Herein, we constructed a paclitaxel (PTX) prodrug (PA) by conjugating PTX with acrylic acid
as a cysteine-depleting agent. The as-synthesized PA can assemble with …