Natural killer cell therapies
E Vivier, L Rebuffet, E Narni-Mancinelli, S Cornen… - Nature, 2024 - nature.com
Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …
NK cell-based immune checkpoint inhibition
Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
The immune system
PJ Delves, IM Roitt - New England journal of medicine, 2000 - Mass Medical Soc
The immune system is an organization of cells and molecules with specialized roles in
defending against infection. There are two fundamentally different types of responses to …
defending against infection. There are two fundamentally different types of responses to …
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
Natural killer cells can discriminate between normal cells and cells that do not express
adequate amounts of major histocompatibility complex (MHC) class I molecules. The …
adequate amounts of major histocompatibility complex (MHC) class I molecules. The …
Escape of human solid tumors from T–cell recognition: Molecular mechanisms and functional significance
FM Marincola, EM Jaffee, DJ Hicklin, S Ferrone - Advances in immunology, 1999 - Elsevier
Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of …
may be associated with the appearance of tumor associated antigens (TAA). Decades of …
KIR: diverse, rapidly evolving receptors of innate and adaptive immunity
C Vilches, P Parham - Annual review of immunology, 2002 - annualreviews.org
KIR genes have evolved in primates to generate a diverse family of receptors with unique
structures that enable them to recognize MHC-class I molecules with locus and allele …
structures that enable them to recognize MHC-class I molecules with locus and allele …
Mechanisms of immune evasion by tumors
In the past decade, basic studies in animal models have begun to elucidate the
physiological barriers which impede a successful antitumor immune response. These …
physiological barriers which impede a successful antitumor immune response. These …
NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non–major histocompatibility complex–restricted tumor …
After culture in interleukin (IL)-2, natural killer (NK) cells acquire an increased capability of
mediating non–major histocompatibility complex (MHC)–restricted tumor cell lysis. This may …
mediating non–major histocompatibility complex (MHC)–restricted tumor cell lysis. This may …
Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
Two major receptors involved in human natural cytotoxicity, NKp46 and NKp44, have
recently been identified. However, experimental evidence suggested the existence of …
recently been identified. However, experimental evidence suggested the existence of …
Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence–derived peptides by CD94/NKG2 confers protection …
F Borrego, M Ulbrecht, EH Weiss, JE Coligan… - The Journal of …, 1998 - rupress.org
Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule,
the gene for which is transcribed in most tissues. It has recently been reported that this …
the gene for which is transcribed in most tissues. It has recently been reported that this …