The role of radiation therapy in the treatment of (colo)-rectal cancer has changed
dramatically over the past decades. Introduced with the aim of reducing the high rates of …

Advances in biotechnology have enabled the collection of an immeasurable amount of
information from genomic, transcriptomic, metabolomic and proteomic studies of tumours …

Abstract Changes in reactive oxygen species (ROS) levels affect many aspects of cell
behavior. During carcinogenesis, moderate ROS production modifies gene expression to …

Background: Studies have examined whether tumor expression of PTGS2 (also known as
COX-2), an enzyme inhibited by nonsteroidal anti-inflammatory drugs such as aspirin, is …

PURPOSE: We aimed to assess the safety and efficacy of preoperative intensity-modulated
radiotherapy (IMRT) with oral capecitabine in patients with locally advanced mid-low rectal …

Results The following specific gene signature, able to discriminate responders' patients from
non-responders, were founded: AKR1C3, CXCL11, CXCL10, IDO1, CXCL9, MMP12 and …

Radiation therapy (RT) can extend its influence in cancer therapy beyond what can be
attributed to in-field cytotoxicity by modulating the immune system. While complex, these …

Although there is increasing appreciation of the role of the host inflammatory response in
determining outcome in patients in colorectal cancer, there has been little concerted effort to …

The purpose of this meta-analysis was to evaluate the efficacy and safety of celecoxib, a
selective cyclooxygenase-2 (COX-2) inhibitor, in addition to standard anticancer therapy …

Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients.
Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side …