Neuroinflammation is one of the host defensive mechanisms through which the nervous
system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation …

Tobacco use disorder continues to be a leading public health issue and cause of premature
death in the United States. Nicotine is considered as the major tobacco alkaloid causing …

Cotinine (COT) and 6-hydroxy-L-nicotine (6HLN) are two nicotinic derivatives that possess
cognitive-improving abilities and antioxidant properties in different rodent models of …

Tobacco smoking is a preventable cause of morbidity and mortality throughout the world.
Smoking comes in form of absorption of many compounds, among which nicotine is the …

Neurodegenerative diseases (NDs) encompass a broad range of conditions characterized
by progressive neuronal degeneration and death and manifesting with a variety of signs and …

Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) in the midbrain …

The number of patients with central nervous system disorders is increasing. Despite diligent
laboratory and clinical research over the past 30 years, most pharmacologic options for the …

Background Paenarthrobacter nicotinovorans ATCC 49919 uses the pyridine-pathway to
degrade nicotine and could provide a renewable source of precursors from nicotine …

Alzheimer's disease (AD) is a neurological disease that causes cognitive impairment,
abnormal behavior, and personality changes, and eventually leads to dementia and death …

The Nicotiana tabacum L. plant, a medicinal resource, holds significant potential for
benefiting human health, as evidenced by its use in Native American and ancient Chinese …