Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses

MG Daskalaki, C Tsatsanis… - Journal of cellular …, 2018 - Wiley Online Library
Macrophages respond to noxious stimuli and contribute to inflammatory responses by
eliminating pathogens or damaged tissue and maintaining homeostasis. Response to …

[HTML][HTML] Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages

AE de Groot, KJ Pienta - Oncotarget, 2018 - ncbi.nlm.nih.gov
The progression of cancer is a result of not only the growth of the malignant cells but also the
behavior of other components of the tumor microenvironment (TME). Tumor-associated …

Klebsiella pneumoniae infection of murine neutrophils impairs their efferocytic clearance by modulating cell death machinery

CN Jondle, K Gupta, BB Mishra, J Sharma - PLoS pathogens, 2018 - journals.plos.org
Neutrophils are the first infiltrating cell type essential for combating pneumoseptic infections
by bacterial pathogens including Klebsiella pneumoniae (KPn). Following an infection or …

Epigenetic control of macrophage polarisation and soluble mediator gene expression during inflammation

TS Kapellos, AJ Iqbal - Mediators of inflammation, 2016 - Wiley Online Library
Macrophages function as sentinel cells, which constantly monitor the host environment for
infection or injury. Macrophages have been shown to exhibit a spectrum of activated …

Two faces of macrophages: Training and tolerance

K Zubair, C You, G Kwon, K Kang - Biomedicines, 2021 - mdpi.com
Macrophages are present in almost all body tissues. They detect and quickly respond to
“environmental signals” in the tissue. Macrophages have been associated with numerous …

Helminths in the gastrointestinal tract as modulators of immunity and pathology

F Varyani, JO Fleming… - American Journal of …, 2017 - journals.physiology.org
Helminth parasites are highly prevalent in many low-and middle-income countries, in which
inflammatory bowel disease and other immunopathologies are less frequent than in the …

Intersection of epigenetic and immune alterations: Implications for fetal alcohol spectrum disorder and mental health

AA Lussier, TS Bodnar, J Weinberg - Frontiers in neuroscience, 2021 - frontiersin.org
Prenatal alcohol exposure can impact virtually all body systems, resulting in a host of
structural, neurocognitive, and behavioral abnormalities. Among the adverse impacts …

Can parasitic worms cure the modern world's ills?

MM Harnett, W Harnett - Trends in parasitology, 2017 - cell.com
There has been increasing recognition that the alarming surge in allergy and autoimmunity
in the industrialised and developing worlds shadows the rapid eradication of pathogens …

Omic” investigations of protozoa and worms for a deeper understanding of the human gut “parasitome

V Marzano, L Mancinelli, G Bracaglia… - PLoS neglected …, 2017 - journals.plos.org
The human gut has been continuously exposed to a broad spectrum of intestinal organisms,
including viruses, bacteria, fungi, and parasites (protozoa and worms), over millions of years …

The role of neuronal factors in the epigenetic reprogramming of microglia in the normal and diseased central nervous system

T Veremeyko, AWY Yung, M Dukhinova… - Frontiers in Cellular …, 2019 - frontiersin.org
Twenty years ago, the scientific community exhibited relatively little interest in the study of
microglial cells. However, recent technical and conceptual advances in this field have …