Targeting furin, a cellular proprotein convertase, for COVID-19 prevention and therapeutics
X Jiang, D Li, M Maghsoudloo, X Zhang, W Ma… - Drug Discovery …, 2024 - Elsevier
Highlights•Furin is a receptor for SARS-CoV-2 and other viruses.•Furin can effectively cleave
a unique S1/S2 site on the SARS-CoV-2 spike protein.•Targeting furin could be a target for …
a unique S1/S2 site on the SARS-CoV-2 spike protein.•Targeting furin could be a target for …
Label-Free Mapping of Multivalent Binding Pathways with Ligand–Receptor-Anchored Nanopores
H Ma, Y Wang, YX Li, BK Xie, ZL Hu… - Journal of the …, 2024 - ACS Publications
Understanding single-molecule multivalent ligand–receptor interactions is crucial for
comprehending molecular recognition at biological interfaces. However, label-free …
comprehending molecular recognition at biological interfaces. However, label-free …
Predictive Factors and ACE-2 Gene Polymorphisms in Susceptibility to Long COVID-19 Syndrome
D Varillas-Delgado, C Jimenez-Antona… - International Journal of …, 2023 - mdpi.com
Long COVID-19 syndrome is present in 5–10% of patients infected with SARS-CoV-2, and
there is still little information on the predisposing factors that lead to its development. The …
there is still little information on the predisposing factors that lead to its development. The …
[PDF][PDF] Genetic Susceptibility to Severe Forms of COVID-19: What We Learned in 2022
R Benmansour, MR Tagajdid, S Elkochri… - Saudi J. Pathol …, 2023 - researchgate.net
Host genetics of COVID-19 patients is constantly evolving and may play an important role in
the management of hospitalized patients and the identification of new biomarkers. In 2022 …
the management of hospitalized patients and the identification of new biomarkers. In 2022 …
Spike mutation profiles associated with SARS-CoV-2 breakthrough infections in Delta emerging and predominant time periods in British Columbia, Canada
Background COVID-19 vaccination is a key public health measure in the pandemic
response. The rapid evolution of SARS-CoV-2 variants introduce new groups of spike …
response. The rapid evolution of SARS-CoV-2 variants introduce new groups of spike …
Evolutionary trajectory of SARS-CoV-2 genome shifts during widespread vaccination and emergence of Omicron variant
Understanding the adaptation of SARS-CoV-2 is critical for the development of effective
treatments against this exceptionally successful human pathogen. To predict the emergence …
treatments against this exceptionally successful human pathogen. To predict the emergence …
Genotype and Haplotype Analysis With In Silico Prediction of TMPRSS2 Gene in Jordanian Population
RI Abu‐Almfalfal, YB Jarrar… - Annals of Human …, 2024 - Wiley Online Library
Background The coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) has rapidly become a global health concern. The …
syndrome coronavirus 2 (SARS‐CoV‐2) has rapidly become a global health concern. The …
Characterization and Structural Prediction of Proteins in SARS-CoV-2 Bangladeshi Variant Through Bioinformatics
The renowned respiratory disease induced by the severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2) has become a global epidemic in just less than a year by the …
coronavirus-2 (SARS-CoV-2) has become a global epidemic in just less than a year by the …
Machine Learning-Enhanced Molecular Dynamics Analysis of Residue Variant Effects on Human ACE2 and Furin Protein Interactions with SARS-CoV-2 Spike
FJ de Almeida Vasquez, AS Fares… - 2024 IEEE Conference …, 2024 - ieeexplore.ieee.org
The interaction between the Spike glycoprotein and its host cell receptors ACE2 and Furin
determines the replication rates of SARS-CoV-2. Given the emergence of variants, the exact …
determines the replication rates of SARS-CoV-2. Given the emergence of variants, the exact …
[HTML][HTML] ACE2 and TMPRSS2 polymorphisms and the development of COVID-19: A review of the literature
AA da Silva Oliveira, AMP da Silva… - … Journal of Clinical …, 2022 - clinvirologyjournal.com
SARS-CoV-2 is a virus that has a positive-sense, single-stranded RNA genome that
encodes 4 structural proteins, the main one being the S protein (Spike) responsible for …
encodes 4 structural proteins, the main one being the S protein (Spike) responsible for …