This manuscript provides a comprehensive review of the peptide and protein identification
process using tandem mass spectrometry (MS/MS) data generated in shotgun proteomic …

Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of
the beating heart. It is unclear whether these cells, which are long-lived and rarely renew …

INTRODUCTION In all eukaryotic cells, lipid droplets (LDs) store and supply essential lipids
to produce signaling molecules, membrane building blocks, and metabolic energy. The LD …

Assembling peptides identified from tandem mass spectra into a list of proteins, referred to
as protein inference, is a critical step in proteomics research. Due to the existence of …

Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …

Exosomes are released by most cells to the extracellular environment and are involved in
cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs …

Human mitochondrial DNA (mtDNA) shows extensive within-population sequence
variability. Many studies suggest that mtDNA variants may be associated with ageing or …

Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference
from glucose to fatty acids for postnatal energy production,. This adaptation is triggered in …

Extracellular vesicles are emerging as a potent mechanism of intercellular communication
because they can systemically exchange genetic and protein material between cells …

Mechanical forces regulate multiple essential pathways in the cell. The nuclear translocation
of mechanoresponsive transcriptional regulators is an essential step for …