Targeting metabolic dysregulation for fibrosis therapy
Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
Alcohol effects on hepatic lipid metabolism
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …
Diet-induced changes in maternal gut microbiota and metabolomic profiles influence programming of offspring obesity risk in rats
Maternal obesity and overnutrition during pregnancy and lactation can program an
increased risk of obesity in offspring. In this context, improving maternal metabolism may …
increased risk of obesity in offspring. In this context, improving maternal metabolism may …
Circulating cytokines as biomarkers of alcohol abuse and alcoholism
There are currently no consistent objective biochemical markers of alcohol abuse and
alcoholism. Development of reliable diagnostic biomarkers that permit accurate assessment …
alcoholism. Development of reliable diagnostic biomarkers that permit accurate assessment …
Rodent models of alcoholic liver disease: of mice and men
E Brandon-Warner, LW Schrum, CM Schmidt… - Alcohol, 2012 - Elsevier
Alcoholic liver disease (ALD) is a major cause of acute and chronic liver disease worldwide.
The progressive nature of ALD is well described; however, the complex interactions under …
The progressive nature of ALD is well described; however, the complex interactions under …
Flow infusion electrospray ionisation mass spectrometry for high throughput, non-targeted metabolite fingerprinting: a review
Producing a comprehensive overview of the chemical content of biologically-derived
material is a major challenge. Apart from ensuring adequate metabolome coverage and …
material is a major challenge. Apart from ensuring adequate metabolome coverage and …
[HTML][HTML] Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication
Background & Aims In experimental models, alcohol induces acute changes in lipid
metabolism that cause hepatocyte lipoapoptosis and inflammation. Here we study human …
metabolism that cause hepatocyte lipoapoptosis and inflammation. Here we study human …
Laboratory models available to study alcohol‐induced organ damage and immune variations: choosing the appropriate model
NB D'Souza El‐Guindy, EJ Kovacs… - Alcoholism: clinical …, 2010 - Wiley Online Library
The morbidity and mortality resulting from alcohol‐related diseases globally impose a
substantive cost to society. To minimize the financial burden on society and improve the …
substantive cost to society. To minimize the financial burden on society and improve the …
High-fat diet augments the effect of alcohol on skeletal muscle mitochondrial dysfunction in mice
A Ismaeel, JA Laudato, E Fletcher, E Papoutsi, A Tice… - Nutrients, 2022 - mdpi.com
Previous studies have shown that chronic heavy alcohol consumption and consumption of a
high-fat (HF) diet can independently contribute to skeletal muscle oxidative stress and …
high-fat (HF) diet can independently contribute to skeletal muscle oxidative stress and …
Recent advances of microbiome-associated metabolomics profiling in liver disease: principles, mechanisms, and applications
Advances in high-throughput screening of metabolic stability in liver and gut microbiota are
able to identify and quantify small-molecule metabolites (metabolome) in different cellular …
able to identify and quantify small-molecule metabolites (metabolome) in different cellular …