The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Structuring liquid oils has become an active area of research in the past decade, mainly due
to pressures to reduce saturated fat intake and eliminate trans fats from our diets. However …

Biologically active sphingolipids have key roles in the regulation of several fundamental
biological processes that are integral to cancer pathogenesis. Recent significant progress in …

Events—The cloning of enzymes that clear ceramide such as GCS and CDases (1, 2), the
generation of knock-out mice in acid SMase (13), and the development/discovery of specific …

Modulation of membrane lipid composition and organization is currently developing as an
effective therapeutic strategy against a wide range of diseases, including cancer. This field …

Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have
clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) …

The sphingolipid ceramide is involved in the cellular stress response. Here we demonstrate
that ceramide controls macroautophagy, a major lysosomal catabolic pathway. Exogenous …

Ceramide, generated by the action of acid sphingomyelinase (ASM), has emerged as a
biochemical mediator of stimuli as diverse as ionizing radiation, chemotherapy, UVA light …

While ceramide has been proposed as a messenger for events as diverse as differentiation,
senescence, proliferation, and cell cycle arrest, a larger body of research has focused on its …

Abstract Ravnskov (1998) presented data for 28 cohorts from 21 prospective studies. In only
3 of these cohorts was saturated fat intake associated with an increased risk of CHD. CHD …