Abstract Development of the forebrain critically depends on the Sonic Hedgehog (Shh)
signaling pathway, as illustrated in humans by the frequent perturbation of this pathway in …

The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that
can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to …

Axonal connections between the left and right sides of the brain are crucial for bilateral
integration of lateralized sensory, motor, and associative functions. Throughout vertebrate …

The primary cilium, a microtubule based organelle protruding from the cell surface and
acting as an antenna in multiple signaling pathways, takes center stage in the formation of …

Highlights•Slit–Robo guide thalamocortical projections from their birthplace to the cortex.•Slit–
Robo regulate radial as well as tangential migration of cortical neurons.•Slit–Robo affect …

Abnormal expression of the transcriptional regulator and hedgehog (Hh) signaling pathway
effector Gli3 is known to trigger congenital disease, most frequently affecting the central …

Primary and motile cilia are thin, hair-like cellular projections from the cell surface involved
in movement, sensing, and communication between cells. Extracellular vesicles (EVs) are …

Agenesis of the corpus callosum (AgCC) is a frequent brain disorder found in over 80
human congenital syndromes including ciliopathies. Here, we report a severe AgCC in …

The corpus callosum connects cerebral hemispheres and is the largest axon tract in the
mammalian brain. Callosal malformations are among the most common congenital brain …

Background PKD1 or PKD2, the two main causal genes for autosomal dominant polycystic
kidney disease (ADPKD), encode the multipass transmembrane proteins polycystin-1 (PC1) …