Memantine (3, 5-dimethyladamantan-1-amine) is an orally active, noncompetitive N-methyl-
D-aspartate receptor (NMDAR) antagonist approved for treatment of moderate-to-severe …

The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …

Nrf2 is a basic leucine zipper transcription factor that binds to the promoter region of the
antioxidant response element (ARE), inducing the coordinated up-regulation of antioxidant …

N-methyl-d-aspartate receptors (NMDAR) are critically involved in the pathogenesis of
Alzheimer's disease (AD). Acting as an open-channel blocker, the anti-AD drug memantine …

An adequate protection from oxidative and inflammatory reactions, together with the
promotion of oligodendrocyte progenitor (OP) differentiation, is needed to recover from …

The skin is the organ that is most susceptible to the impact of the exposome. Located at the
interface with the external environment, it protects internal organs through the barrier …

Antioxidant systems play key roles in many elderly diseases, including age-related macular
degeneration (AMD). Oxidative stress, autophagy impairment and inflammation are well …

Age-related macular degeneration (AMD) is a common disease with a multifactorial
aetiology, still lacking effective and curative therapies. Among the early events triggering …

The transcription factor Nrf2 coordinates a multifaceted response to various forms of stress
and to inflammatory processes, maintaining a homeostatic intracellular environment. Nrf2 …

Oxidative stress and neuroinflammation play a pivotal role in triggering the
neurodegenerative pathological cascades which characterize neurodegenerative disorders …