Fetuin-A: a novel link between obesity and related complications
JF Trepanowski, J Mey, KA Varady - International journal of obesity, 2015 - nature.com
Fetuin-A (FetA) is a 64-kDa glycoprotein that is secreted from both the liver and adipose
tissue. Circulating FetA is elevated in obesity and related disorders including type 2 diabetes …
tissue. Circulating FetA is elevated in obesity and related disorders including type 2 diabetes …
Clinical implications of fetuin-A
P Jirak, L Stechemesser, E Moré, M Franzen… - Advances in clinical …, 2019 - Elsevier
Fetuin-A, also termed alpha2-Heremans-Schmid glycoprotein, is a 46 kDa hepatocyte
derived protein (hepatokine) and serves multifaceted functions.(i) It acts as systemic inhibitor …
derived protein (hepatokine) and serves multifaceted functions.(i) It acts as systemic inhibitor …
Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene
ST Mathews, GP Singh, M Ranalletta, VJ Cintron… - Diabetes, 2002 - Am Diabetes Assoc
Fetuin inhibits insulin-induced insulin receptor (IR) autophosphorylation and tyrosine kinase
activity in vitro, in intact cells, and in vivo. The fetuin gene (AHSG) is located on human …
activity in vitro, in intact cells, and in vivo. The fetuin gene (AHSG) is located on human …
α2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor
ST Mathews, N Chellam, PR Srinivas, VJ Cintron… - Molecular and cellular …, 2000 - Elsevier
Human fetuin,(α2-Heremans Schmid Glycoprotein (α2-HSG)], is a natural inhibitor of insulin
receptor tyrosine kinase activity (IR-TKA). Previously, we have demonstrated that α2-HSG …
receptor tyrosine kinase activity (IR-TKA). Previously, we have demonstrated that α2-HSG …
Similar albeit not the same: in-depth analysis of proteoforms of human serum, bovine serum, and recombinant human fetuin
Fetuin, also known as alpha-2-Heremans Schmid glycoprotein (AHSG), belongs to some of
the most abundant glycoproteins secreted into the bloodstream. In blood, fetuins exhibit …
the most abundant glycoproteins secreted into the bloodstream. In blood, fetuins exhibit …
The “thrifty” gene encoding Ahsg/Fetuin-A meets the insulin receptor: Insights into the mechanism of insulin resistance
AS Goustin, AB Abou-Samra - Cellular signalling, 2011 - Elsevier
Ahsg (fetuin-A) is a 55–59kDa phosphorylated glycoprotein synthesized in the adult
predominantly by hepatocytes, from which it enters the circulation. When dysregulated, this …
predominantly by hepatocytes, from which it enters the circulation. When dysregulated, this …
Ahsg-fetuin blocks the metabolic arm of insulin action through its interaction with the 95-kD β-subunit of the insulin receptor
AS Goustin, N Derar, AB Abou-Samra - Cellular signalling, 2013 - Elsevier
We previously have shown that Ahsg, a liver glycoprotein, inhibits insulin receptor (InsR)
tyrosine kinase (TK) activity and the ERK1/2 mitogenic signaling arm of insulin signaling …
tyrosine kinase (TK) activity and the ERK1/2 mitogenic signaling arm of insulin signaling …
Phosphorylation of human plasma α2-Heremans–Schmid glycoprotein (human fetuin) in vivo
ÅC Haglund, B Ek, P Ek - Biochemical Journal, 2001 - portlandpress.com
A fraction of α2-Heremans–Schmid (α2-HS) glycoprotein (human fetuin) isolated from
plasma was phosphorylated at serine-120 and serine-312 as shown by MS and peptide …
plasma was phosphorylated at serine-120 and serine-312 as shown by MS and peptide …
Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase
ST Mathews, PR Srinivas, MA Leon, G Grunberger - Life sciences, 1997 - Elsevier
Fetuin has been identified earlier as the bovine homolog of the human plasma protein, α2-
Heremans Schmid grycoprotein (α2-HSG). Although bovine fetuin shares over 70% ammo …
Heremans Schmid grycoprotein (α2-HSG). Although bovine fetuin shares over 70% ammo …
Phosphorylation status of fetuin-A is critical for inhibition of insulin action and is correlated with obesity and insulin resistance
G Ren, T Kim, JB Papizan… - American Journal …, 2019 - journals.physiology.org
Fetuin-A (Fet-A), a hepatokine associated with insulin resistance, obesity, and incident type
2 diabetes, is shown to exist in both phosphorylated and dephosphorylated forms in …
2 diabetes, is shown to exist in both phosphorylated and dephosphorylated forms in …