The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

G protein-coupled receptors (GPCRs) transduce a wide array of extracellular signals and
regulate virtually every aspect of physiology. While GPCR signaling is essential …

G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors
transmitting extracellular signals into cells. Here we show that central components of a …

G protein-independent, arrestin-dependent signaling is a paradigm that broadens the
signaling scope of G protein-coupled receptors (GPCRs) beyond G proteins for numerous …

Classically, G protein-coupled receptor (GPCR) stimulation promotes G protein signaling at
the plasma membrane, followed by rapid β-arrestin-mediated desensitization and receptor …

Cells interpret a variety of signals through G-protein-coupled receptors (GPCRs) and
stimulate the generation of second messengers such as cyclic adenosine monophosphate …

β-Arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G
protein signaling, to initiate signaling on their own, and to mediate receptor endocytosis …

G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …

Arrestins interact with G protein–coupled receptors (GPCRs) to stop G protein activation and
to initiate key signaling pathways. Recent structural studies shed light on the molecular …